FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions

C9ORF72 repeat expansion is the most common genetic mutation in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Abnormal dipeptide repeat proteins (DPRs) generated from repeat-associated non-AUG (RAN) translation of repeat-containing RNAs are thought to be pathogenic; however,...

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Detalles Bibliográficos
Autores principales: Yang, Dejun, Abdallah, Abbas, Li, Zhaodong, Lu, Yubing, Almeida, Sandra, Gao, Fen-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575383/
https://www.ncbi.nlm.nih.gov/pubmed/26031661
http://dx.doi.org/10.1007/s00401-015-1448-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575383/
https://www.ncbi.nlm.nih.gov/pubmed/26031661
http://dx.doi.org/10.1007/s00401-015-1448-6

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