Cargando…

Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease

Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD). The physiological capacity of peripheral tissues and organs in clearing brain-derived Aβ and its therapeutic potential for AD remains largely unknown. Here, we measured blood Aβ levels in different locations of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiang, Yang, Bu, Xian-Le, Liu, Yu-Hui, Zhu, Chi, Shen, Lin-Lin, Jiao, Shu-Sheng, Zhu, Xiao-Yan, Giunta, Brian, Tan, Jun, Song, Wei-Hong, Zhou, Hua-Dong, Zhou, Xin-Fu, Wang, Yan-Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2015
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575389/ https://www.ncbi.nlm.nih.gov/pubmed/26363791 http://dx.doi.org/10.1007/s00401-015-1477-1

Ejemplares similares

Editorial on, “Amyloid-beta clearance in Alzheimer's disease”
por: Marr, Robert A.
Publicado: (2014)

Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance
por: Marr, Robert A., et al.
Publicado: (2014)

The Correlations of Plasma and Cerebrospinal Fluid Amyloid-Beta Levels with Platelet Count in Patients with Alzheimer's Disease
por: Sun, Hao-Lun, et al.
Publicado: (2018)

Advances in Amyloid-β Clearance in the Brain and Periphery: Implications for Neurodegenerative Diseases
por: Ullah, Rahat, et al.
Publicado: (2023)

Physiological clearance of Aβ by spleen and splenectomy aggravates Alzheimer‐type pathogenesis
por: Yu, Zhong‐Yuan, et al.
Publicado: (2021)

An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect
por: Liu, Yu-Hui, et al.
Publicado: (2015)

Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
por: Wang, Jun, et al.
Publicado: (2020)

Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome
por: Bu, Xian-Le, et al.
Publicado: (2015)

Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance
por: Malm, Tarja, et al.
Publicado: (2012)

Heat Shock Proteins and Amateur Chaperones in Amyloid-Beta Accumulation and Clearance in Alzheimer’s Disease
por: Wilhelmus, Micha M. M., et al.
Publicado: (2007)

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease
por: Yao, X-Q, et al.
Publicado: (2015)

The Correlations Between Plasma Fibrinogen With Amyloid-Beta and Tau Levels in Patients With Alzheimer’s Disease
por: Fan, Dong-Yu, et al.
Publicado: (2021)

Amyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer’s disease
por: Chen, Si-Han, et al.
Publicado: (2020)

The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease
por: ElAli, Ayman, et al.
Publicado: (2013)

Anticoagulants inhibit proteolytic clearance of plasma amyloid beta
por: Yang, Lu, et al.
Publicado: (2017)

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease
por: Kanekiyo, Takahisa, et al.
Publicado: (2014)

Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease
por: Semyachkina-Glushkovskaya, Oxana, et al.
Publicado: (2021)

Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
por: Li, Yi, et al.
Publicado: (2022)

Evidence for impaired amyloid β clearance in Alzheimer's disease
por: Wildsmith, Kristin R, et al.
Publicado: (2013)

Electroacupuncture Improves Clearance of Amyloid-β through the Glymphatic System in the SAMP8 Mouse Model of Alzheimer's Disease
por: Liang, Pei-zhe, et al.
Publicado: (2021)

Increased tauopathy drives microglia-mediated clearance of beta-amyloid
por: Chen, Wesley, et al.
Publicado: (2016)

Clearance of amyloid‐beta with bispecific antibody constructs bound to erythrocytes
por: Taylor, Ronald P., et al.
Publicado: (2020)

Microglial amyloid beta clearance is driven by PIEZO1 channels
por: Jäntti, Henna, et al.
Publicado: (2022)

The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets
por: Qi, Xue-mei, et al.
Publicado: (2017)

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1
por: Ramanathan, Anita, et al.
Publicado: (2015)

Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease
por: González-Marrero, Ibrahim, et al.
Publicado: (2015)

NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease
por: He, Xiao-fei, et al.
Publicado: (2020)

Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease
por: Wijesinghe, Printha, et al.
Publicado: (2023)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice
por: He, Xiao-fei, et al.
Publicado: (2017)

Therapeutic Potential of Direct Clearance of the Amyloid-β in Alzheimer’s Disease
por: Kim, Dong Eun, et al.
Publicado: (2020)

Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance
por: Feng, Weixi, et al.
Publicado: (2020)

Correction to: NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease
por: He, Xiao-fei, et al.
Publicado: (2022)

The Amyloid-Beta Clearance: From Molecular Targets to Glial and Neural Cells
por: Cai, Wenjun, et al.
Publicado: (2023)

Amyloid Beta in Aging and Alzheimer’s Disease
por: Sehar, Ujala, et al.
Publicado: (2022)

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance
por: Pan, Rui-Yuan, et al.
Publicado: (2019)

Amyloid-beta Alzheimer targets — protein processing, lipid rafts, and amyloid-beta pores
por: Arbor, Sage C., et al.
Publicado: (2016)

The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer’s Disease
por: Yin, Xiaomin, et al.
Publicado: (2021)

Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model
por: Yuede, Carla M., et al.
Publicado: (2016)

Protective Factors Modulate the Risk of Beta Amyloid in Alzheimer's Disease
por: Zhou, Bin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6p3vd7cl59r8fli8j4oksfb9tl