Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process

BACKGROUND: The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this pathway cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition. Upon DNA damage, normal and FA cells inhibit the cell cycle progression, until the G2/M check...

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Detalles Bibliográficos
Autores principales: Rodríguez, Alfredo, Torres, Leda, Juárez, Ulises, Sosa, David, Azpeitia, Eugenio, Teresa, Benilde García-de, Cortés, Edith, Ortíz, Rocío, Salazar, Ana M., Ostrosky-Wegman, Patricia, Mendoza, Luis, Frías, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575447/
https://www.ncbi.nlm.nih.gov/pubmed/26385365
http://dx.doi.org/10.1186/s12976-015-0011-4

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