Histone Reader BRWD1 Targets and Restricts Recombination to the Igk Locus

B lymphopoiesis requires that immunoglobulin genes be accessible to the RAG1-RAG2 recombinase. However, the RAG proteins bind widely to open chromatin suggesting that additional mechanisms must restrict RAG-mediated DNA cleavage. Here, we demonstrate developmental downregulation of interleukin 7 (IL...

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Detalles Bibliográficos
Autores principales: Mandal, Malay, Hamel, Keith M., Maienschein-Cline, Mark, Tanaka, Azusa, Teng, Grace, Tuteja, Jigyasa H., Bunker, Jeffrey J., Bahroos, Neil, Eppig, John J., Schatz, David G., Clark, Marcus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575638/
https://www.ncbi.nlm.nih.gov/pubmed/26301565
http://dx.doi.org/10.1038/ni.3249

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