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Working memory training impacts the mean diffusivity in the dopaminergic system
Dopaminergic transmission plays a critical role in working memory (WM). Mean diffusivity (MD) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system. Despite previous investigation of the effects of WM training (WMT)...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575686/ https://www.ncbi.nlm.nih.gov/pubmed/25023736 http://dx.doi.org/10.1007/s00429-014-0845-2 |
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author | Takeuchi, Hikaru Taki, Yasuyuki Nouchi, Rui Hashizume, Hiroshi Sekiguchi, Atsushi Kotozaki, Yuka Nakagawa, Seishu Miyauchi, Carlos Makoto Sassa, Yuko Kawashima, Ryuta |
author_facet | Takeuchi, Hikaru Taki, Yasuyuki Nouchi, Rui Hashizume, Hiroshi Sekiguchi, Atsushi Kotozaki, Yuka Nakagawa, Seishu Miyauchi, Carlos Makoto Sassa, Yuko Kawashima, Ryuta |
author_sort | Takeuchi, Hikaru |
collection | PubMed |
description | Dopaminergic transmission plays a critical role in working memory (WM). Mean diffusivity (MD) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system. Despite previous investigation of the effects of WM training (WMT) on dopamine receptor binding potentials, the effects of WMT on MD remain unknown. In this study, we investigated these effects in young adult subjects who either underwent WMT or received no intervention for 4 weeks. Before and after the intervention or no-intervention periods, subjects underwent scanning sessions in diffusion-weighted imaging to measure MD. Compared with no intervention, WMT resulted in an increase in MD in the bilateral caudate, right putamen, left dorsolateral prefrontal cortex (DLPFC), right anterior cingulate cortex (ACC), right substantia nigra, and ventral tegmental area. Furthermore, the increase in performance on WMT tasks was significantly positively correlated with the mean increase in MD in the clusters of the left DLPFC and of the right ACC. These results suggest that WMT caused microstructural changes in the regions of the dopaminergic system in a way that is usually interpreted as a reduction in neural components. |
format | Online Article Text |
id | pubmed-4575686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-45756862015-09-24 Working memory training impacts the mean diffusivity in the dopaminergic system Takeuchi, Hikaru Taki, Yasuyuki Nouchi, Rui Hashizume, Hiroshi Sekiguchi, Atsushi Kotozaki, Yuka Nakagawa, Seishu Miyauchi, Carlos Makoto Sassa, Yuko Kawashima, Ryuta Brain Struct Funct Original Article Dopaminergic transmission plays a critical role in working memory (WM). Mean diffusivity (MD) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system. Despite previous investigation of the effects of WM training (WMT) on dopamine receptor binding potentials, the effects of WMT on MD remain unknown. In this study, we investigated these effects in young adult subjects who either underwent WMT or received no intervention for 4 weeks. Before and after the intervention or no-intervention periods, subjects underwent scanning sessions in diffusion-weighted imaging to measure MD. Compared with no intervention, WMT resulted in an increase in MD in the bilateral caudate, right putamen, left dorsolateral prefrontal cortex (DLPFC), right anterior cingulate cortex (ACC), right substantia nigra, and ventral tegmental area. Furthermore, the increase in performance on WMT tasks was significantly positively correlated with the mean increase in MD in the clusters of the left DLPFC and of the right ACC. These results suggest that WMT caused microstructural changes in the regions of the dopaminergic system in a way that is usually interpreted as a reduction in neural components. Springer Berlin Heidelberg 2014-07-15 2015 /pmc/articles/PMC4575686/ /pubmed/25023736 http://dx.doi.org/10.1007/s00429-014-0845-2 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Article Takeuchi, Hikaru Taki, Yasuyuki Nouchi, Rui Hashizume, Hiroshi Sekiguchi, Atsushi Kotozaki, Yuka Nakagawa, Seishu Miyauchi, Carlos Makoto Sassa, Yuko Kawashima, Ryuta Working memory training impacts the mean diffusivity in the dopaminergic system |
title | Working memory training impacts the mean diffusivity in the dopaminergic system |
title_full | Working memory training impacts the mean diffusivity in the dopaminergic system |
title_fullStr | Working memory training impacts the mean diffusivity in the dopaminergic system |
title_full_unstemmed | Working memory training impacts the mean diffusivity in the dopaminergic system |
title_short | Working memory training impacts the mean diffusivity in the dopaminergic system |
title_sort | working memory training impacts the mean diffusivity in the dopaminergic system |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575686/ https://www.ncbi.nlm.nih.gov/pubmed/25023736 http://dx.doi.org/10.1007/s00429-014-0845-2 |
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