Cargando…

Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype

The unconventional myosin VI, a member of the actin-based motor protein family of myosins, is expressed in the retina. Its deletion was previously shown to reduce amplitudes of the a- and b-waves of the electroretinogram. Analyzing wild-type and myosin VI-deficient Snell’s Waltzer mice in more detai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schubert, Timm, Gleiser, Corinna, Heiduschka, Peter, Franz, Christoph, Nagel-Wolfrum, Kerstin, Sahaboglu, Ayse, Weisschuh, Nicole, Eske, Gordon, Rohbock, Karin, Rieger, Norman, Paquet-Durand, François, Wissinger, Bernd, Wolfrum, Uwe, Hirt, Bernhard, Singer, Wibke, Rüttiger, Lukas, Zimmermann, Ulrike, Knipper, Marlies
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Basel 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575690/ https://www.ncbi.nlm.nih.gov/pubmed/25939269 http://dx.doi.org/10.1007/s00018-015-1913-3

Ejemplares similares

Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms
por: Sahaboglu, A, et al.
Publicado: (2013)

The Reduced Cochlear Output and the Failure to Adapt the Central Auditory Response Causes Tinnitus in Noise Exposed Rats
por: Rüttiger, Lukas, et al.
Publicado: (2013)

USH2A variants causing retinitis pigmentosa or Usher syndrome provoke differential retinal phenotypes in disease-specific organoids
por: Sanjurjo-Soriano, Carla, et al.
Publicado: (2023)

Specific synaptopathies diversify brain responses and hearing disorders: you lose the gain from early life
por: Knipper, Marlies, et al.
Publicado: (2015)

PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal Function
por: Sahaboglu, Ayse, et al.
Publicado: (2010)

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration
por: Sahaboglu, Ayse, et al.
Publicado: (2016)

Efficacy of PARP inhibition in Pde6a mutant mouse models for retinitis pigmentosa depends on the quality and composition of individual human mutations
por: Jiao, K, et al.
Publicado: (2016)

Retinal Remodeling and Metabolic Alterations in Human AMD
por: Jones, Bryan W., et al.
Publicado: (2016)

cGMP-Prkg1 signaling PDE5 inhibition shelter cochlear hair cells and hearing function
por: Knipper, Marlies, et al.
Publicado: (2013)

CDHR1 mutations in retinal dystrophies
por: Stingl, Katarina, et al.
Publicado: (2017)

A Homozygous Mutation in the TUB Gene Associated with Retinal Dystrophy and Obesity
por: Borman, Arundhati Dev, et al.
Publicado: (2014)

Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea
por: Marchetta, Philine, et al.
Publicado: (2022)

X-Linked Retinitis Pigmentosa Caused by Non-Canonical Splice Site Variants in RPGR
por: Kortüm, Friederike, et al.
Publicado: (2021)

L-type Ca(V)1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for Ca(V)1.2-mediated control of cochlear BDNF expression
por: Zuccotti, Annalisa, et al.
Publicado: (2013)

Visual Function in Eyes with Intermediate AMD with and without Retinal Pigment Abnormalities
por: Schneck, Marilyn E., et al.
Publicado: (2021)

Automatic Detection of AMD and DME Retinal Pathologies Using Deep Learning
por: Saidi, Latifa, et al.
Publicado: (2023)

Disturbed Balance of Inhibitory Signaling Links Hearing Loss and Cognition
por: Knipper, Marlies, et al.
Publicado: (2022)

Translational Read-Through Drugs (TRIDs) Are Able to Restore Protein Expression and Ciliogenesis in Fibroblasts of Patients with Retinitis Pigmentosa Caused by a Premature Termination Codon in FAM161A
por: Beryozkin, Avigail, et al.
Publicado: (2022)

Central Visual Function and Genotype–Phenotype Correlations in PDE6A-Associated Retinitis Pigmentosa
por: Kuehlewein, Laura, et al.
Publicado: (2022)

Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue
por: Kawa, Milosz P., et al.
Publicado: (2014)

Glial Cells in the Fish Retinal Nerve Fiber Layer Form Tight Junctions, Separating and Surrounding Axons
por: Garcia-Pradas, Lidia, et al.
Publicado: (2018)

Visualizing BDNF Transcript Usage During Sound-Induced Memory Linked Plasticity
por: Matt, Lucas, et al.
Publicado: (2018)

Translational read-through of the RP2 Arg120stop mutation in patient iPSC-derived retinal pigment epithelium cells
por: Schwarz, Nele, et al.
Publicado: (2015)

Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration
por: Arango-Gonzalez, Blanca, et al.
Publicado: (2014)

A retinal model of cerebral malaria
por: Paquet-Durand, François, et al.
Publicado: (2019)

Age-Dependent Auditory Processing Deficits after Cochlear Synaptopathy Depend on Auditory Nerve Latency and the Ability of the Brain to Recruit LTP/BDNF
por: Marchetta, Philine, et al.
Publicado: (2020)

Functional biomarkers that distinguish between tinnitus with and without hyperacusis
por: Hofmeier, Benedikt, et al.
Publicado: (2021)

Drug delivery to retinal photoreceptors
por: Himawan, Erico, et al.
Publicado: (2019)

A new mouse model for retinal degeneration due to Fam161a deficiency
por: Beryozkin, Avigail, et al.
Publicado: (2021)

An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD
por: Zekavat, Seyedeh Maryam, et al.
Publicado: (2017)

Cytotoxicity of β-Cyclodextrins in Retinal Explants for Intravitreal Drug Formulations
por: Prajapati, Manisha, et al.
Publicado: (2021)

Imaging Ca(2+) Dynamics in Cone Photoreceptor Axon Terminals of the Mouse Retina
por: Kulkarni, Manoj, et al.
Publicado: (2015)

Stress Affects Central Compensation of Neural Responses to Cochlear Synaptopathy in a cGMP-Dependent Way
por: Savitska, Daria, et al.
Publicado: (2022)

Clinical Phenotype of PDE6B-Associated Retinitis Pigmentosa
por: Kuehlewein, Laura, et al.
Publicado: (2021)

Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats
por: Markovets, Anton M., et al.
Publicado: (2010)

Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD
por: Schütze, Christopher, et al.
Publicado: (2016)

Microstructure of the retinal pigment epithelium near-infrared autofluorescence in healthy young eyes and in patients with AMD
por: Vienola, Kari V., et al.
Publicado: (2020)

Gene-based treatment options for Usher type 1C by translational read-through of a nonsense mutation
por: Wolfrum, U, et al.
Publicado: (2012)

Using Micro-Electrode-Array Recordings and Retinal Disease Models to Elucidate Visual Functions: Simultaneous Recording of Local Electroretinograms and Ganglion Cell Action Potentials Reveals the Origin of Retinal Oscillatory Potentials
por: Haq, Wadood, et al.
Publicado: (2023)

Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for EYS-Associated Retinitis Pigmentosa
por: Schellens, Renske, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m73p5efd9374ksst12ql1tlh0o