Critical residues involved in Toll-like receptor 4 activation by cationic lipid nanocarriers are not located at the lipopolysaccharide-binding interface

DiC14-amidine is a cationic lipid that was originally designed as a lipid nanocarrier for nucleic acid transport, and turned out to be a Toll-like receptor 4 (TLR4) agonist as well. We found that while E. coli lipopolysaccharide (LPS) is a TLR4 agonist in all species, diC14-amidine nanoliposomes are...

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Detalles Bibliográficos
Autores principales: Lonez, Caroline, Irvine, Kate L., Pizzuto, Malvina, Schmidt, Boris I., Gay, Nick J., Ruysschaert, Jean-Marie, Gangloff, Monique, Bryant, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575701/
https://www.ncbi.nlm.nih.gov/pubmed/25956320
http://dx.doi.org/10.1007/s00018-015-1915-1

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