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Safety and Efficacy of Intravenous Colistin in Neonates With Culture Proven Sepsis

BACKGROUND: Although it is well described among adults, intravenous colistin use and its associated toxicities in newborns are poorly understood. OBJECTIVES: We present our experience of efficacy and safety of intravenous colistin in the treatment of sepsis in term and preterm neonates. PATIENTS AND...

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Autores principales: Serafettin Tekgunduz, Kadir, Kara, Mustafa, Caner, Ibrahim, Demirelli, Yasar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575804/
https://www.ncbi.nlm.nih.gov/pubmed/26396706
http://dx.doi.org/10.5812/ijp.453
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author Serafettin Tekgunduz, Kadir
Kara, Mustafa
Caner, Ibrahim
Demirelli, Yasar
author_facet Serafettin Tekgunduz, Kadir
Kara, Mustafa
Caner, Ibrahim
Demirelli, Yasar
author_sort Serafettin Tekgunduz, Kadir
collection PubMed
description BACKGROUND: Although it is well described among adults, intravenous colistin use and its associated toxicities in newborns are poorly understood. OBJECTIVES: We present our experience of efficacy and safety of intravenous colistin in the treatment of sepsis in term and preterm neonates. PATIENTS AND METHODS: The records of neonates who received colistin between January 2013 and February 2014 were retrospectively reviewed. All neonates with culture proven nosocomial infections due to multidrug resistant organisms and treated continuously with colistin for more than 72 hours were included in the study. RESULTS: Patients were evaluated for clinical and microbiological response to the drug and its and side effects. Twelve newborn infants with mean 31.8 ± 3.5 weeks gestational age and median 1482 (810 - 3200) gram birth weight were included. 11/12 (91.7%) patients showed microbiological clearance with intravenous colistin. One patient who had recurrent cerebrospinal fluid positive culture was treated with intraventricular colistin. The major side effects observed was hyponatremia and hypokalemia in 2 (16.6%) patients, all infants required magnesium supplementation. CONCLUSIONS: Intravenous colistin administration appears to be safe and efficacious for multidrug-resistant gram-negative infections in neonates, including preterm infants. However, we believe that large prospective controlled studies are needed to confirm its efficacy and safety in neonates.
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spelling pubmed-45758042015-09-22 Safety and Efficacy of Intravenous Colistin in Neonates With Culture Proven Sepsis Serafettin Tekgunduz, Kadir Kara, Mustafa Caner, Ibrahim Demirelli, Yasar Iran J Pediatr Research Article BACKGROUND: Although it is well described among adults, intravenous colistin use and its associated toxicities in newborns are poorly understood. OBJECTIVES: We present our experience of efficacy and safety of intravenous colistin in the treatment of sepsis in term and preterm neonates. PATIENTS AND METHODS: The records of neonates who received colistin between January 2013 and February 2014 were retrospectively reviewed. All neonates with culture proven nosocomial infections due to multidrug resistant organisms and treated continuously with colistin for more than 72 hours were included in the study. RESULTS: Patients were evaluated for clinical and microbiological response to the drug and its and side effects. Twelve newborn infants with mean 31.8 ± 3.5 weeks gestational age and median 1482 (810 - 3200) gram birth weight were included. 11/12 (91.7%) patients showed microbiological clearance with intravenous colistin. One patient who had recurrent cerebrospinal fluid positive culture was treated with intraventricular colistin. The major side effects observed was hyponatremia and hypokalemia in 2 (16.6%) patients, all infants required magnesium supplementation. CONCLUSIONS: Intravenous colistin administration appears to be safe and efficacious for multidrug-resistant gram-negative infections in neonates, including preterm infants. However, we believe that large prospective controlled studies are needed to confirm its efficacy and safety in neonates. Kowsar 2015-08-24 2015-08 /pmc/articles/PMC4575804/ /pubmed/26396706 http://dx.doi.org/10.5812/ijp.453 Text en Copyright © 2015, Growth & Development Research Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Serafettin Tekgunduz, Kadir
Kara, Mustafa
Caner, Ibrahim
Demirelli, Yasar
Safety and Efficacy of Intravenous Colistin in Neonates With Culture Proven Sepsis
title Safety and Efficacy of Intravenous Colistin in Neonates With Culture Proven Sepsis
title_full Safety and Efficacy of Intravenous Colistin in Neonates With Culture Proven Sepsis
title_fullStr Safety and Efficacy of Intravenous Colistin in Neonates With Culture Proven Sepsis
title_full_unstemmed Safety and Efficacy of Intravenous Colistin in Neonates With Culture Proven Sepsis
title_short Safety and Efficacy of Intravenous Colistin in Neonates With Culture Proven Sepsis
title_sort safety and efficacy of intravenous colistin in neonates with culture proven sepsis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575804/
https://www.ncbi.nlm.nih.gov/pubmed/26396706
http://dx.doi.org/10.5812/ijp.453
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