Cargando…

Neonatal Morbidities Associated with Histologic Chorioamnionitis Defined Based on the Site and Extent of Inflammation in Very Low Birth Weight Infants

Conflicting results on the influences of histologic chorioamnionitis (HC) on neonatal morbidities might be partly originated from using different definition of HC. The aim of this study was to determine the relationship between HC and neonatal morbidities using definition of HC that reflects the sit...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Su Yeong, Choi, Chang Won, Jung, Euiseok, Lee, Juyoung, Lee, Jin A, Kim, Haeryoung, Kim, Ee-Kyung, Kim, Han-Suk, Kim, Beyong Il, Choi, Jung-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575938/
https://www.ncbi.nlm.nih.gov/pubmed/26425046
http://dx.doi.org/10.3346/jkms.2015.30.10.1476
_version_ 1782390829170556928
author Kim, Su Yeong
Choi, Chang Won
Jung, Euiseok
Lee, Juyoung
Lee, Jin A
Kim, Haeryoung
Kim, Ee-Kyung
Kim, Han-Suk
Kim, Beyong Il
Choi, Jung-Hwan
author_facet Kim, Su Yeong
Choi, Chang Won
Jung, Euiseok
Lee, Juyoung
Lee, Jin A
Kim, Haeryoung
Kim, Ee-Kyung
Kim, Han-Suk
Kim, Beyong Il
Choi, Jung-Hwan
author_sort Kim, Su Yeong
collection PubMed
description Conflicting results on the influences of histologic chorioamnionitis (HC) on neonatal morbidities might be partly originated from using different definition of HC. The aim of this study was to determine the relationship between HC and neonatal morbidities using definition of HC that reflects the site and extent of inflammation. This was a retrospective cohort study of 261 very low birth weight (VLBW) infants admitted at a tertiary academic center. Based on the site of inflammation, HC was categorized: any HC; amnionitis; funisitis; amnionitis+funisitis. The extent of inflammation in each site was reflected by sub-defining high grade (HG). The incidences of morbidities in infants with and without HC were compared. The bronchopulmonary dysplasia (BPD) rate was significantly higher in infants with amnionitis and the severe retinopathy of prematurity (ROP) rate was significantly higher in infants with any HC and funisitis. After adjustment for both gestational age and birth weight, the respiratory distress syndrome (RDS) rate was significantly lower in infants with all categories of HC except for HG amnionitis and HG funisitis, which are not associated with lower RDS rate. HG amnionitis was significantly associated with increased BPD rate but the association of HC with severe ROP disappeared. In conclusion, HC is significantly associated with decreased RDS and HG amnionitis with increased BPD while lacking association with other neonatal morbidities in VLBW infants. The association with HC and neonatal morbidities differs by the site and extent of chorioamnionitis. GRAPHICAL ABSTRACT: [Image: see text]
format Online
Article
Text
id pubmed-4575938
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-45759382015-10-01 Neonatal Morbidities Associated with Histologic Chorioamnionitis Defined Based on the Site and Extent of Inflammation in Very Low Birth Weight Infants Kim, Su Yeong Choi, Chang Won Jung, Euiseok Lee, Juyoung Lee, Jin A Kim, Haeryoung Kim, Ee-Kyung Kim, Han-Suk Kim, Beyong Il Choi, Jung-Hwan J Korean Med Sci Original Article Conflicting results on the influences of histologic chorioamnionitis (HC) on neonatal morbidities might be partly originated from using different definition of HC. The aim of this study was to determine the relationship between HC and neonatal morbidities using definition of HC that reflects the site and extent of inflammation. This was a retrospective cohort study of 261 very low birth weight (VLBW) infants admitted at a tertiary academic center. Based on the site of inflammation, HC was categorized: any HC; amnionitis; funisitis; amnionitis+funisitis. The extent of inflammation in each site was reflected by sub-defining high grade (HG). The incidences of morbidities in infants with and without HC were compared. The bronchopulmonary dysplasia (BPD) rate was significantly higher in infants with amnionitis and the severe retinopathy of prematurity (ROP) rate was significantly higher in infants with any HC and funisitis. After adjustment for both gestational age and birth weight, the respiratory distress syndrome (RDS) rate was significantly lower in infants with all categories of HC except for HG amnionitis and HG funisitis, which are not associated with lower RDS rate. HG amnionitis was significantly associated with increased BPD rate but the association of HC with severe ROP disappeared. In conclusion, HC is significantly associated with decreased RDS and HG amnionitis with increased BPD while lacking association with other neonatal morbidities in VLBW infants. The association with HC and neonatal morbidities differs by the site and extent of chorioamnionitis. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2015-10 2015-09-12 /pmc/articles/PMC4575938/ /pubmed/26425046 http://dx.doi.org/10.3346/jkms.2015.30.10.1476 Text en © 2015 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Su Yeong
Choi, Chang Won
Jung, Euiseok
Lee, Juyoung
Lee, Jin A
Kim, Haeryoung
Kim, Ee-Kyung
Kim, Han-Suk
Kim, Beyong Il
Choi, Jung-Hwan
Neonatal Morbidities Associated with Histologic Chorioamnionitis Defined Based on the Site and Extent of Inflammation in Very Low Birth Weight Infants
title Neonatal Morbidities Associated with Histologic Chorioamnionitis Defined Based on the Site and Extent of Inflammation in Very Low Birth Weight Infants
title_full Neonatal Morbidities Associated with Histologic Chorioamnionitis Defined Based on the Site and Extent of Inflammation in Very Low Birth Weight Infants
title_fullStr Neonatal Morbidities Associated with Histologic Chorioamnionitis Defined Based on the Site and Extent of Inflammation in Very Low Birth Weight Infants
title_full_unstemmed Neonatal Morbidities Associated with Histologic Chorioamnionitis Defined Based on the Site and Extent of Inflammation in Very Low Birth Weight Infants
title_short Neonatal Morbidities Associated with Histologic Chorioamnionitis Defined Based on the Site and Extent of Inflammation in Very Low Birth Weight Infants
title_sort neonatal morbidities associated with histologic chorioamnionitis defined based on the site and extent of inflammation in very low birth weight infants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575938/
https://www.ncbi.nlm.nih.gov/pubmed/26425046
http://dx.doi.org/10.3346/jkms.2015.30.10.1476
work_keys_str_mv AT kimsuyeong neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants
AT choichangwon neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants
AT jungeuiseok neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants
AT leejuyoung neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants
AT leejina neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants
AT kimhaeryoung neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants
AT kimeekyung neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants
AT kimhansuk neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants
AT kimbeyongil neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants
AT choijunghwan neonatalmorbiditiesassociatedwithhistologicchorioamnionitisdefinedbasedonthesiteandextentofinflammationinverylowbirthweightinfants