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Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis

Therapeutic plasma exchange (TPE) is one possible treatment for patients resistant to conventional antithyroid drugs or requiring urgent attention for thyrotoxicosis. We report a 35-yr-old man with thyrotoxicosis, ultimately attributed to Graves' disease in whom antithyroid drug used initially...

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Autores principales: Min, Se Hee, Phung, Anita, Oh, Tae Jung, Han, Kyou-Sup, Kim, Man Jin, Kim, Jee Min, Lee, Ji hyun, Park, Young Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575946/
https://www.ncbi.nlm.nih.gov/pubmed/26425054
http://dx.doi.org/10.3346/jkms.2015.30.10.1531
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author Min, Se Hee
Phung, Anita
Oh, Tae Jung
Han, Kyou-Sup
Kim, Man Jin
Kim, Jee Min
Lee, Ji hyun
Park, Young Joo
author_facet Min, Se Hee
Phung, Anita
Oh, Tae Jung
Han, Kyou-Sup
Kim, Man Jin
Kim, Jee Min
Lee, Ji hyun
Park, Young Joo
author_sort Min, Se Hee
collection PubMed
description Therapeutic plasma exchange (TPE) is one possible treatment for patients resistant to conventional antithyroid drugs or requiring urgent attention for thyrotoxicosis. We report a 35-yr-old man with thyrotoxicosis, ultimately attributed to Graves' disease in whom antithyroid drug used initially was soon discontinued, due to abnormal liver function, and replaced by Lugol's solution. Three weeks later, an escape phenomenon (to Lugol's solution) was apparent, so we performed TPE to control the thyrotoxicosis. Two courses of TPE by a centrifugal type machine resulted in diminished levels of thyroid hormone levels, which then rebounded after another two courses of membrane filtration type TPE. However, the patient could be treated with radioactive iodine therapy without any complications at present. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-45759462015-10-01 Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis Min, Se Hee Phung, Anita Oh, Tae Jung Han, Kyou-Sup Kim, Man Jin Kim, Jee Min Lee, Ji hyun Park, Young Joo J Korean Med Sci Case Report Therapeutic plasma exchange (TPE) is one possible treatment for patients resistant to conventional antithyroid drugs or requiring urgent attention for thyrotoxicosis. We report a 35-yr-old man with thyrotoxicosis, ultimately attributed to Graves' disease in whom antithyroid drug used initially was soon discontinued, due to abnormal liver function, and replaced by Lugol's solution. Three weeks later, an escape phenomenon (to Lugol's solution) was apparent, so we performed TPE to control the thyrotoxicosis. Two courses of TPE by a centrifugal type machine resulted in diminished levels of thyroid hormone levels, which then rebounded after another two courses of membrane filtration type TPE. However, the patient could be treated with radioactive iodine therapy without any complications at present. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2015-10 2015-09-12 /pmc/articles/PMC4575946/ /pubmed/26425054 http://dx.doi.org/10.3346/jkms.2015.30.10.1531 Text en © 2015 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Min, Se Hee
Phung, Anita
Oh, Tae Jung
Han, Kyou-Sup
Kim, Man Jin
Kim, Jee Min
Lee, Ji hyun
Park, Young Joo
Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis
title Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis
title_full Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis
title_fullStr Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis
title_full_unstemmed Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis
title_short Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis
title_sort therapeutic plasmapheresis enabling radioactive iodine treatment in a patient with thyrotoxicosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575946/
https://www.ncbi.nlm.nih.gov/pubmed/26425054
http://dx.doi.org/10.3346/jkms.2015.30.10.1531
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