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External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis
Objective. To evaluate the effectiveness of external application of traditional Chinese medicine (EA-TCM) on venous ulcers. Methods. Seven databases were searched until April 2015 for randomized controlled trials (RCTs) of EA-TCM for venous ulcers. Risk of bias was assessed using Cochrane Handbook g...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576005/ https://www.ncbi.nlm.nih.gov/pubmed/26435725 http://dx.doi.org/10.1155/2015/831474 |
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author | Li, Xin Xiao, Qing-qing Ze, Kan Li, Su Wang, Yi-fei Zhou, Min Yang, Qin-tong Li, Fu-lun Li, Bin |
author_facet | Li, Xin Xiao, Qing-qing Ze, Kan Li, Su Wang, Yi-fei Zhou, Min Yang, Qin-tong Li, Fu-lun Li, Bin |
author_sort | Li, Xin |
collection | PubMed |
description | Objective. To evaluate the effectiveness of external application of traditional Chinese medicine (EA-TCM) on venous ulcers. Methods. Seven databases were searched until April 2015 for randomized controlled trials (RCTs) of EA-TCM for venous ulcers. Risk of bias was assessed using Cochrane Handbook guidelines. Study outcomes were presented as risk ratios (RRs) for dichotomous data or mean differences (MDs) for continuous data. Results. Sixteen of 193 potentially relevant trials met the inclusion criteria; however, their methodological qualities were low. Comparison of the same intervention strategies revealed significant differences in total effectiveness rates between EA-TCM and conventional therapy groups (RR = 1.22, 95% confidence interval [CI] = 1.16–1.29, and P < 0.00001). Compared to conventional therapy, EA-TCM combined with conventional therapy had a superior total effectiveness rate (RR = 1.11, 95% CI = 1.04–1.19, and P = 0.003). There were no significant differences in recurrence rates during followup and final pain measurements between the experimental and those in the control groups (RR = 0.86, 95% CI = 0.31–2.39, and P = 0.85; MD −0.75, 95% CI = −2.15–0.65, and P = 0.29). Conclusion. The evidence that EA-TCM is an effective treatment for venous ulcers is encouraging, but not conclusive due to the low methodological quality of the RCTs. Therefore, more high-quality RCTs with larger sample sizes are required. |
format | Online Article Text |
id | pubmed-4576005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45760052015-10-04 External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis Li, Xin Xiao, Qing-qing Ze, Kan Li, Su Wang, Yi-fei Zhou, Min Yang, Qin-tong Li, Fu-lun Li, Bin Evid Based Complement Alternat Med Review Article Objective. To evaluate the effectiveness of external application of traditional Chinese medicine (EA-TCM) on venous ulcers. Methods. Seven databases were searched until April 2015 for randomized controlled trials (RCTs) of EA-TCM for venous ulcers. Risk of bias was assessed using Cochrane Handbook guidelines. Study outcomes were presented as risk ratios (RRs) for dichotomous data or mean differences (MDs) for continuous data. Results. Sixteen of 193 potentially relevant trials met the inclusion criteria; however, their methodological qualities were low. Comparison of the same intervention strategies revealed significant differences in total effectiveness rates between EA-TCM and conventional therapy groups (RR = 1.22, 95% confidence interval [CI] = 1.16–1.29, and P < 0.00001). Compared to conventional therapy, EA-TCM combined with conventional therapy had a superior total effectiveness rate (RR = 1.11, 95% CI = 1.04–1.19, and P = 0.003). There were no significant differences in recurrence rates during followup and final pain measurements between the experimental and those in the control groups (RR = 0.86, 95% CI = 0.31–2.39, and P = 0.85; MD −0.75, 95% CI = −2.15–0.65, and P = 0.29). Conclusion. The evidence that EA-TCM is an effective treatment for venous ulcers is encouraging, but not conclusive due to the low methodological quality of the RCTs. Therefore, more high-quality RCTs with larger sample sizes are required. Hindawi Publishing Corporation 2015 2015-09-07 /pmc/articles/PMC4576005/ /pubmed/26435725 http://dx.doi.org/10.1155/2015/831474 Text en Copyright © 2015 Xin Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Li, Xin Xiao, Qing-qing Ze, Kan Li, Su Wang, Yi-fei Zhou, Min Yang, Qin-tong Li, Fu-lun Li, Bin External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis |
title | External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis |
title_full | External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis |
title_fullStr | External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis |
title_full_unstemmed | External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis |
title_short | External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis |
title_sort | external application of traditional chinese medicine for venous ulcers: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576005/ https://www.ncbi.nlm.nih.gov/pubmed/26435725 http://dx.doi.org/10.1155/2015/831474 |
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