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Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies

Treatment of Aspergillus fumigatus with echinocandins such as caspofungin inhibits the synthesis of cell wall β-1,3-glucan, which triggers a compensatory stimulation of chitin synthesis. Activation of chitin synthesis can occur in response to sub-MICs of caspofungin and to CaCl(2) and calcofluor whi...

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Detalles Bibliográficos
Autores principales:	Walker, Louise A., Lee, Keunsook K., Munro, Carol A., Gow, Neil A. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2015
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576100/ https://www.ncbi.nlm.nih.gov/pubmed/26169407 http://dx.doi.org/10.1128/AAC.00862-15

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