FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy

Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function. FHL1 increased the myostatin activity on a SM...

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Detalles Bibliográficos
Autores principales: Lee, Jen Y., Lori, Dede, Wells, Dominic J., Kemp, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576159/
https://www.ncbi.nlm.nih.gov/pubmed/26504741
http://dx.doi.org/10.1016/j.fob.2015.08.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576159/
https://www.ncbi.nlm.nih.gov/pubmed/26504741
http://dx.doi.org/10.1016/j.fob.2015.08.011

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