Translational Control of the HIV Unspliced Genomic RNA

Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicin...

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Autores principales: Rojas-Araya, Bárbara, Ohlmann, Théophile, Soto-Rifo, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576183/
https://www.ncbi.nlm.nih.gov/pubmed/26247956
http://dx.doi.org/10.3390/v7082822
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author Rojas-Araya, Bárbara
Ohlmann, Théophile
Soto-Rifo, Ricardo
author_facet Rojas-Araya, Bárbara
Ohlmann, Théophile
Soto-Rifo, Ricardo
author_sort Rojas-Araya, Bárbara
collection PubMed
description Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.
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spelling pubmed-45761832015-09-28 Translational Control of the HIV Unspliced Genomic RNA Rojas-Araya, Bárbara Ohlmann, Théophile Soto-Rifo, Ricardo Viruses Review Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP. MDPI 2015-08-04 /pmc/articles/PMC4576183/ /pubmed/26247956 http://dx.doi.org/10.3390/v7082822 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rojas-Araya, Bárbara
Ohlmann, Théophile
Soto-Rifo, Ricardo
Translational Control of the HIV Unspliced Genomic RNA
title Translational Control of the HIV Unspliced Genomic RNA
title_full Translational Control of the HIV Unspliced Genomic RNA
title_fullStr Translational Control of the HIV Unspliced Genomic RNA
title_full_unstemmed Translational Control of the HIV Unspliced Genomic RNA
title_short Translational Control of the HIV Unspliced Genomic RNA
title_sort translational control of the hiv unspliced genomic rna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576183/
https://www.ncbi.nlm.nih.gov/pubmed/26247956
http://dx.doi.org/10.3390/v7082822
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