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PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation

P21-activated kinases (PAKs) are multifunctional effectors of Rho GTPases with both kinase and scaffolding activity. Here, we investigated the effects of inflammation on PAK1 signaling and its role in colitis-driven carcinogenesis. PAK1 and p-PAK1 (Thr423) were assessed by immunohistochemistry, immu...

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Detalles Bibliográficos
Autores principales:	Dammann, Kyle, Khare, Vineeta, Lang, Michaela, Claudel, Thierry, Harpain, Felix, Granofszky, Nicolas, Evstatiev, Rayko, Williams, Jonathan M., Pritchard, D. Mark, Watson, Alastair, Gasche, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Pub. Co 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576212/ https://www.ncbi.nlm.nih.gov/pubmed/26036343 http://dx.doi.org/10.1016/j.bbamcr.2015.05.031

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