Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature

Hyperammonemia is an uncommon side effect of topiramate (TPM) that has only been reported when it is used as an adjunct to valproate. We report a patient with mental retardation who developed reversible encephalopathy from TPM. Ammonia level was monitored during the course of TPM treatment. This pat...

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Autores principales: Tantikittichaikul, Sahawat, Johnson, Justine, Laengvejkal, Pavis, DeToledo, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576360/
https://www.ncbi.nlm.nih.gov/pubmed/26543812
http://dx.doi.org/10.1016/j.ebcr.2014.09.001
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author Tantikittichaikul, Sahawat
Johnson, Justine
Laengvejkal, Pavis
DeToledo, John
author_facet Tantikittichaikul, Sahawat
Johnson, Justine
Laengvejkal, Pavis
DeToledo, John
author_sort Tantikittichaikul, Sahawat
collection PubMed
description Hyperammonemia is an uncommon side effect of topiramate (TPM) that has only been reported when it is used as an adjunct to valproate. We report a patient with mental retardation who developed reversible encephalopathy from TPM. Ammonia level was monitored during the course of TPM treatment. This patient had recurring, reversible elevations in serum ammonia levels that coincided with the administration of TPM. To our knowledge, symptomatic hyperammonemia has not been reported to occur with TPM monotherapy.
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spelling pubmed-45763602015-11-05 Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature Tantikittichaikul, Sahawat Johnson, Justine Laengvejkal, Pavis DeToledo, John Epilepsy Behav Case Rep Case Report Hyperammonemia is an uncommon side effect of topiramate (TPM) that has only been reported when it is used as an adjunct to valproate. We report a patient with mental retardation who developed reversible encephalopathy from TPM. Ammonia level was monitored during the course of TPM treatment. This patient had recurring, reversible elevations in serum ammonia levels that coincided with the administration of TPM. To our knowledge, symptomatic hyperammonemia has not been reported to occur with TPM monotherapy. Elsevier 2015-09-15 /pmc/articles/PMC4576360/ /pubmed/26543812 http://dx.doi.org/10.1016/j.ebcr.2014.09.001 Text en © 2014 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Case Report
Tantikittichaikul, Sahawat
Johnson, Justine
Laengvejkal, Pavis
DeToledo, John
Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature
title Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature
title_full Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature
title_fullStr Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature
title_full_unstemmed Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature
title_short Topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: A case report and review of the literature
title_sort topiramate-induced hyperammonemic encephalopathy in a patient with mental retardation: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576360/
https://www.ncbi.nlm.nih.gov/pubmed/26543812
http://dx.doi.org/10.1016/j.ebcr.2014.09.001
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