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Outcome of assisted reproductive technology in women aged 40 years and older
BACKGROUND: Human fertility has been declined all over the world. Advanced women’s age is one of the most important factors in determining the success of reproduction and ageing has negative impact on ART outcome and advanced female age decreases the chance of live birth rates achieved using ART, es...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research and Clinical Center for Infertility
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576428/ https://www.ncbi.nlm.nih.gov/pubmed/26396576 |
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author | Aflatoonian, Abbas Eftekhar, Maryam Mohammadian, Farnaz Yousefnejad, Fariba |
author_facet | Aflatoonian, Abbas Eftekhar, Maryam Mohammadian, Farnaz Yousefnejad, Fariba |
author_sort | Aflatoonian, Abbas |
collection | PubMed |
description | BACKGROUND: Human fertility has been declined all over the world. Advanced women’s age is one of the most important factors in determining the success of reproduction and ageing has negative impact on ART outcome and advanced female age decreases the chance of live birth rates achieved using ART, especially after 40 years of age. OBJECTIVE: To evaluate ART outcomes regarding to pregnancy, abortion, cycle cancellation and live birth rates in women 40 years and older. MATERIALS AND METHODS: A retrospective study was performed on three hundred-thirteen women undergoing ART cycles in the Madar Hospital in Yazd. Women with age ≥ 40 years who indicated for ART enrolled the study regardless of the infertility type or etiology. In this study, we used data from IVF or ICSI cycles using fresh embryo transfer. Follow up was performed in regard to pregnancy, abortion, cycle cancellation and live birth rates. RESULTS: The mean age of women was 41.87±1.97 years. Chemical pregnancy rate was 8.6% (27/313) per cycle. Clinical pregnancy rate was 3.8% (12/313) per cycle. Spontaneous abortion was observed in 63% (17/27) of patients with positive pregnancy test. The overall cancellation rate was 23.3% per oocytes retrieval. The overall live birth rate per cycle for all women who initiated an ART cycle at age ≥40 years was 3.2% (10/313) that eight of those women were under 42 years old. CONCLUSION: Based on our results, we suggest that women with age 42 years and above should be advised to use other options, including oocyte donation or adoption. |
format | Online Article Text |
id | pubmed-4576428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Research and Clinical Center for Infertility |
record_format | MEDLINE/PubMed |
spelling | pubmed-45764282015-09-22 Outcome of assisted reproductive technology in women aged 40 years and older Aflatoonian, Abbas Eftekhar, Maryam Mohammadian, Farnaz Yousefnejad, Fariba Iran J Reprod Med Original Article BACKGROUND: Human fertility has been declined all over the world. Advanced women’s age is one of the most important factors in determining the success of reproduction and ageing has negative impact on ART outcome and advanced female age decreases the chance of live birth rates achieved using ART, especially after 40 years of age. OBJECTIVE: To evaluate ART outcomes regarding to pregnancy, abortion, cycle cancellation and live birth rates in women 40 years and older. MATERIALS AND METHODS: A retrospective study was performed on three hundred-thirteen women undergoing ART cycles in the Madar Hospital in Yazd. Women with age ≥ 40 years who indicated for ART enrolled the study regardless of the infertility type or etiology. In this study, we used data from IVF or ICSI cycles using fresh embryo transfer. Follow up was performed in regard to pregnancy, abortion, cycle cancellation and live birth rates. RESULTS: The mean age of women was 41.87±1.97 years. Chemical pregnancy rate was 8.6% (27/313) per cycle. Clinical pregnancy rate was 3.8% (12/313) per cycle. Spontaneous abortion was observed in 63% (17/27) of patients with positive pregnancy test. The overall cancellation rate was 23.3% per oocytes retrieval. The overall live birth rate per cycle for all women who initiated an ART cycle at age ≥40 years was 3.2% (10/313) that eight of those women were under 42 years old. CONCLUSION: Based on our results, we suggest that women with age 42 years and above should be advised to use other options, including oocyte donation or adoption. Research and Clinical Center for Infertility 2011 /pmc/articles/PMC4576428/ /pubmed/26396576 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Aflatoonian, Abbas Eftekhar, Maryam Mohammadian, Farnaz Yousefnejad, Fariba Outcome of assisted reproductive technology in women aged 40 years and older |
title | Outcome of assisted reproductive technology in women aged 40 years and older |
title_full | Outcome of assisted reproductive technology in women aged 40 years and older |
title_fullStr | Outcome of assisted reproductive technology in women aged 40 years and older |
title_full_unstemmed | Outcome of assisted reproductive technology in women aged 40 years and older |
title_short | Outcome of assisted reproductive technology in women aged 40 years and older |
title_sort | outcome of assisted reproductive technology in women aged 40 years and older |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576428/ https://www.ncbi.nlm.nih.gov/pubmed/26396576 |
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