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DisVis: quantifying and visualizing accessible interaction space of distance-restrained biomolecular complexes

Summary: We present DisVis, a Python package and command line tool to calculate the reduced accessible interaction space of distance-restrained binary protein complexes, allowing for direct visualization and quantification of the information content of the distance restraints. The approach is genera...

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Detalles Bibliográficos
Autores principales: van Zundert, G.C.P., Bonvin, A.M.J.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576694/
https://www.ncbi.nlm.nih.gov/pubmed/26026169
http://dx.doi.org/10.1093/bioinformatics/btv333
Descripción
Sumario:Summary: We present DisVis, a Python package and command line tool to calculate the reduced accessible interaction space of distance-restrained binary protein complexes, allowing for direct visualization and quantification of the information content of the distance restraints. The approach is general and can also be used as a knowledge-based distance energy term in FFT-based docking directly during the sampling stage. Availability and implementation: The source code with documentation is freely available from https://github.com/haddocking/disvis. Contact: a.m.j.j.bonvin@uu.nl Supplementary information: Supplementary data are available at Bioinformatics online.