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Phenotypic differences in nebivolol metabolism and bioavailability in healthy volunteers

INTRODUCTION: Nebivolol, a third-generation β-blocker, is subject to extensive first-pass metabolism and produces active β-blocking hydroxylated metabolites, like 4-OH-nebivolol. It is primarily a substrate of CYP2D6, a metabolic pathway that is under polymorphic genetic regulation. The objective of...

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Detalles Bibliográficos
Autores principales:	BRICIU, CORINA, NEAG, MARIA, MUNTEAN, DANA, BOCSAN, CORINA, BUZOIANU, ANCA, ANTONESCU, OANA, GHELDIU, ANA-MARIA, ACHIM, MARCELA, POPA, ADINA, VLASE, LAURIAN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Iuliu Hatieganu University of Medicine and Pharmacy 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576779/ https://www.ncbi.nlm.nih.gov/pubmed/26528073 http://dx.doi.org/10.15386/cjmed-395

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