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Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) has attracted much research attention around the world, and the number of ESCC cases has increased gradually in recent years. Identifying the specific biomarkers of ESCC is an effective approach for the early diagnosis of tumors. MATERIAL/METHODS...

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Autores principales: Zhang, Yan, Liao, Ruyi, Li, Hui, Liu, Ling, Chen, Xiao, Chen, Hongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576925/
https://www.ncbi.nlm.nih.gov/pubmed/26344167
http://dx.doi.org/10.12659/MSM.895242
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author Zhang, Yan
Liao, Ruyi
Li, Hui
Liu, Ling
Chen, Xiao
Chen, Hongming
author_facet Zhang, Yan
Liao, Ruyi
Li, Hui
Liu, Ling
Chen, Xiao
Chen, Hongming
author_sort Zhang, Yan
collection PubMed
description BACKGROUND: Esophageal squamous cell carcinoma (ESCC) has attracted much research attention around the world, and the number of ESCC cases has increased gradually in recent years. Identifying the specific biomarkers of ESCC is an effective approach for the early diagnosis of tumors. MATERIAL/METHODS: Immunohistochemical streptavidin-peroxidase method was used to determine the expressions of Cofilin-1 and transgelin in 68 patients with esophageal squamous cell carcinoma (ESCC) and 48 individuals with normal esophageal tissues. In addition to the relationships between the expression of Cofilin-1 and transgelin, the clinicopathologic features of ESCC were also discussed. The correlation between Cofilin-1 and transgelin protein expression in ESCC was analyzed. RESULTS: (1) The positive expression rates of Cofilin-1 and transgelin were 60.3% (41/68) and 54.4% (37/68) in esophageal carcinoma tissue, respectively. The positive expression rates of Cofilin-1 and transgelin in normal esophageal tissue were 27.1% (13/48) and 29.1% (14/48), respectively. The differences were statistically significant (P<0.05). (2) The positive expression rate of Cofilin-1 did not differ significantly (P>0.05) with sex, age, ethnicity, tumor size, or infiltration depth; but did have a statistically significant (P<0.05) difference with various degrees of tumor differentiation, lymph node metastasis, and clinical stages. (3) The positive expression rate of transgelin did not differ significantly (P>0.05) with sex, age, ethnicity, tumor size, infiltration depth, and clinical stage, but did significantly (P<0.05) differ with degree of tumor differentiation and lymph node metastasis. CONCLUSIONS: Cofilin-1 and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma. Cofilin-1 may be useful as an important biomarker for indicating the degree of malignancy of esophageal squamous cell carcinoma, and the detection of transgelin is valuable in early diagnosis of esophageal squamous cell carcinoma.
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spelling pubmed-45769252015-09-30 Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma Zhang, Yan Liao, Ruyi Li, Hui Liu, Ling Chen, Xiao Chen, Hongming Med Sci Monit Clinical Research BACKGROUND: Esophageal squamous cell carcinoma (ESCC) has attracted much research attention around the world, and the number of ESCC cases has increased gradually in recent years. Identifying the specific biomarkers of ESCC is an effective approach for the early diagnosis of tumors. MATERIAL/METHODS: Immunohistochemical streptavidin-peroxidase method was used to determine the expressions of Cofilin-1 and transgelin in 68 patients with esophageal squamous cell carcinoma (ESCC) and 48 individuals with normal esophageal tissues. In addition to the relationships between the expression of Cofilin-1 and transgelin, the clinicopathologic features of ESCC were also discussed. The correlation between Cofilin-1 and transgelin protein expression in ESCC was analyzed. RESULTS: (1) The positive expression rates of Cofilin-1 and transgelin were 60.3% (41/68) and 54.4% (37/68) in esophageal carcinoma tissue, respectively. The positive expression rates of Cofilin-1 and transgelin in normal esophageal tissue were 27.1% (13/48) and 29.1% (14/48), respectively. The differences were statistically significant (P<0.05). (2) The positive expression rate of Cofilin-1 did not differ significantly (P>0.05) with sex, age, ethnicity, tumor size, or infiltration depth; but did have a statistically significant (P<0.05) difference with various degrees of tumor differentiation, lymph node metastasis, and clinical stages. (3) The positive expression rate of transgelin did not differ significantly (P>0.05) with sex, age, ethnicity, tumor size, infiltration depth, and clinical stage, but did significantly (P<0.05) differ with degree of tumor differentiation and lymph node metastasis. CONCLUSIONS: Cofilin-1 and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma. Cofilin-1 may be useful as an important biomarker for indicating the degree of malignancy of esophageal squamous cell carcinoma, and the detection of transgelin is valuable in early diagnosis of esophageal squamous cell carcinoma. International Scientific Literature, Inc. 2015-09-07 /pmc/articles/PMC4576925/ /pubmed/26344167 http://dx.doi.org/10.12659/MSM.895242 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Zhang, Yan
Liao, Ruyi
Li, Hui
Liu, Ling
Chen, Xiao
Chen, Hongming
Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma
title Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma
title_full Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma
title_fullStr Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma
title_full_unstemmed Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma
title_short Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma
title_sort expression of cofilin-1 and transgelin in esophageal squamous cell carcinoma
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576925/
https://www.ncbi.nlm.nih.gov/pubmed/26344167
http://dx.doi.org/10.12659/MSM.895242
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