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The usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study
OBJECTIVE: Recent studies have shown that sex and age are associated with outcomes in patients with cardiomyopathy. The purpose of this study was to determine the all-cause mortality of dilated cardiomyopathy (DCM) by age and sex. METHODS AND RESULTS: The patients were divided into non-elderly (age...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577275/ https://www.ncbi.nlm.nih.gov/pubmed/26396507 http://dx.doi.org/10.2147/CIA.S88565 |
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author | Li, Xiaoping Cai, Chi Luo, Rong Jiang, Rongjian Zeng, Jie Tang, Yijia Chen, Yang Fu, Michael He, Tao Hua, Wei |
author_facet | Li, Xiaoping Cai, Chi Luo, Rong Jiang, Rongjian Zeng, Jie Tang, Yijia Chen, Yang Fu, Michael He, Tao Hua, Wei |
author_sort | Li, Xiaoping |
collection | PubMed |
description | OBJECTIVE: Recent studies have shown that sex and age are associated with outcomes in patients with cardiomyopathy. The purpose of this study was to determine the all-cause mortality of dilated cardiomyopathy (DCM) by age and sex. METHODS AND RESULTS: The patients were divided into non-elderly (age <60 years, n=811) and elderly (age ≥60 years, n=331) groups. No difference in the all-cause mortality rate was observed between elderly and non-elderly patients (27.2% vs 22.2%, log-rank χ(2)=2.604, P=0.107). Furthermore, no significant difference in mortality was observed between the male and female patients (23.3% vs 24.5%, log-rank χ(2)=0.707, P=0.400). However, subgroup analysis revealed that elderly male patients exhibited a higher mortality rate than non-elderly male patients (29.4% vs 21.3%, log-rank χ(2)=5.898, P=0.015), while no difference was observed between the elderly female patients and non-elderly female patients. In the Cox analysis, neither age nor sex was a significant independent predictor of all-cause mortality in patients with DCM. CONCLUSION: In conclusion, no significant difference in mortality between male and female patients or between the elderly and non-elderly patients was observed. Only among males was a difference in mortality observed; elderly male patients experienced greater mortality than that of non-elderly male patients. No effect of age or sex on all-cause mortality was observed in patients with DCM. |
format | Online Article Text |
id | pubmed-4577275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45772752015-09-22 The usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study Li, Xiaoping Cai, Chi Luo, Rong Jiang, Rongjian Zeng, Jie Tang, Yijia Chen, Yang Fu, Michael He, Tao Hua, Wei Clin Interv Aging Original Research OBJECTIVE: Recent studies have shown that sex and age are associated with outcomes in patients with cardiomyopathy. The purpose of this study was to determine the all-cause mortality of dilated cardiomyopathy (DCM) by age and sex. METHODS AND RESULTS: The patients were divided into non-elderly (age <60 years, n=811) and elderly (age ≥60 years, n=331) groups. No difference in the all-cause mortality rate was observed between elderly and non-elderly patients (27.2% vs 22.2%, log-rank χ(2)=2.604, P=0.107). Furthermore, no significant difference in mortality was observed between the male and female patients (23.3% vs 24.5%, log-rank χ(2)=0.707, P=0.400). However, subgroup analysis revealed that elderly male patients exhibited a higher mortality rate than non-elderly male patients (29.4% vs 21.3%, log-rank χ(2)=5.898, P=0.015), while no difference was observed between the elderly female patients and non-elderly female patients. In the Cox analysis, neither age nor sex was a significant independent predictor of all-cause mortality in patients with DCM. CONCLUSION: In conclusion, no significant difference in mortality between male and female patients or between the elderly and non-elderly patients was observed. Only among males was a difference in mortality observed; elderly male patients experienced greater mortality than that of non-elderly male patients. No effect of age or sex on all-cause mortality was observed in patients with DCM. Dove Medical Press 2015-09-16 /pmc/articles/PMC4577275/ /pubmed/26396507 http://dx.doi.org/10.2147/CIA.S88565 Text en © 2015 Li et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Li, Xiaoping Cai, Chi Luo, Rong Jiang, Rongjian Zeng, Jie Tang, Yijia Chen, Yang Fu, Michael He, Tao Hua, Wei The usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study |
title | The usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study |
title_full | The usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study |
title_fullStr | The usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study |
title_full_unstemmed | The usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study |
title_short | The usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study |
title_sort | usefulness of age and sex to predict all-cause mortality in patients with dilated cardiomyopathy: a single-center cohort study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577275/ https://www.ncbi.nlm.nih.gov/pubmed/26396507 http://dx.doi.org/10.2147/CIA.S88565 |
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