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Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B

Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. Negative regulation of ANGPT1 by KDM3B is independent of its Jumonji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction wi...

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Detalles Bibliográficos
Autores principales:	Han, Arim, Chae, Yun-Cheol, Park, Jin Woo, Kim, Kee-Beom, Kim, Ji-Young, Seo, Sang-Beom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2015
Materias:	Research-Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577290/ https://www.ncbi.nlm.nih.gov/pubmed/25413303 http://dx.doi.org/10.5483/BMBRep.2015.48.7.188

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