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The effect of estrogen on muscle damage biomarkers following prolonged aerobic exercise in eumenorrheic women
This study assessed the influence of estrogen (E(2)) on muscle damage biomarkers [skeletal muscle - creatine kinase (CK); cardiac muscle - CK-MB] responses to prolonged aerobic exercise. Eumenorrheic women (n=10) who were physically active completed two 60-minute treadmill running sessions at ∼60-65...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Institute of Sport in Warsaw
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577556/ https://www.ncbi.nlm.nih.gov/pubmed/26424921 http://dx.doi.org/10.5604/20831862.1150300 |
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author | Williams, T Walz, E Lane, AR Pebole, M Hackney, AC |
author_facet | Williams, T Walz, E Lane, AR Pebole, M Hackney, AC |
author_sort | Williams, T |
collection | PubMed |
description | This study assessed the influence of estrogen (E(2)) on muscle damage biomarkers [skeletal muscle - creatine kinase (CK); cardiac muscle - CK-MB] responses to prolonged aerobic exercise. Eumenorrheic women (n=10) who were physically active completed two 60-minute treadmill running sessions at ∼60-65% maximal intensity during low E(2) (midfollicular menstrual phase) and high E(2) (midluteal menstrual phase) hormonal conditions. Blood samples were collected prior to exercise (following supine rest), immediately post-, 30 min post-, and 24 hours post-exercise to determine changes in muscle biomarkers. Resting blood samples confirmed appropriate E(2) hormonal levels Total CK concentrations increased following exercise and at 24 hours post-exercise were higher in the midfollicular low E(2) phase (p<0.001). However, CK-MB concentrations were unaffected by E(2) level or exercise (p=0.442) resulting in the ratio of CK-MB to total CK being consistently low in subject responses (i.e., indicative of skeletal muscle damage). Elevated E(2) levels reduce the CK responses of skeletal muscle, but had no effect on CK-MB responses following prolonged aerobic exercise. These findings support earlier work showing elevated E(2) is protective of skeletal muscle from exercise-induced damage associated with prolonged aerobic exercise. |
format | Online Article Text |
id | pubmed-4577556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Institute of Sport in Warsaw |
record_format | MEDLINE/PubMed |
spelling | pubmed-45775562015-09-30 The effect of estrogen on muscle damage biomarkers following prolonged aerobic exercise in eumenorrheic women Williams, T Walz, E Lane, AR Pebole, M Hackney, AC Biol Sport Original Article This study assessed the influence of estrogen (E(2)) on muscle damage biomarkers [skeletal muscle - creatine kinase (CK); cardiac muscle - CK-MB] responses to prolonged aerobic exercise. Eumenorrheic women (n=10) who were physically active completed two 60-minute treadmill running sessions at ∼60-65% maximal intensity during low E(2) (midfollicular menstrual phase) and high E(2) (midluteal menstrual phase) hormonal conditions. Blood samples were collected prior to exercise (following supine rest), immediately post-, 30 min post-, and 24 hours post-exercise to determine changes in muscle biomarkers. Resting blood samples confirmed appropriate E(2) hormonal levels Total CK concentrations increased following exercise and at 24 hours post-exercise were higher in the midfollicular low E(2) phase (p<0.001). However, CK-MB concentrations were unaffected by E(2) level or exercise (p=0.442) resulting in the ratio of CK-MB to total CK being consistently low in subject responses (i.e., indicative of skeletal muscle damage). Elevated E(2) levels reduce the CK responses of skeletal muscle, but had no effect on CK-MB responses following prolonged aerobic exercise. These findings support earlier work showing elevated E(2) is protective of skeletal muscle from exercise-induced damage associated with prolonged aerobic exercise. Institute of Sport in Warsaw 2015-04-24 2015-09 /pmc/articles/PMC4577556/ /pubmed/26424921 http://dx.doi.org/10.5604/20831862.1150300 Text en Copyright © Biology of Sport 2015 http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Williams, T Walz, E Lane, AR Pebole, M Hackney, AC The effect of estrogen on muscle damage biomarkers following prolonged aerobic exercise in eumenorrheic women |
title | The effect of estrogen on muscle damage biomarkers following prolonged aerobic exercise in eumenorrheic women |
title_full | The effect of estrogen on muscle damage biomarkers following prolonged aerobic exercise in eumenorrheic women |
title_fullStr | The effect of estrogen on muscle damage biomarkers following prolonged aerobic exercise in eumenorrheic women |
title_full_unstemmed | The effect of estrogen on muscle damage biomarkers following prolonged aerobic exercise in eumenorrheic women |
title_short | The effect of estrogen on muscle damage biomarkers following prolonged aerobic exercise in eumenorrheic women |
title_sort | effect of estrogen on muscle damage biomarkers following prolonged aerobic exercise in eumenorrheic women |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577556/ https://www.ncbi.nlm.nih.gov/pubmed/26424921 http://dx.doi.org/10.5604/20831862.1150300 |
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