Cargando…

Tumors of the Central Nervous System: An 18-Year Retrospective Review in a Tertiary Pediatric Referral Center

OBJECTIVE: Few studies exist on the demographics and trends of pediatric central nervous system (CNS) tumors in Iran. In this study, we retrospectively reviewed all cases with confirmed CNS tumors admitted to Mofid Pediatric Hospital, Tehran, Iran during the last 18 years. MATERIALS & METHODS: D...

Descripción completa

Detalles Bibliográficos
Autores principales: AGHAYAN GOLKASHANI, Hosein, HATAMI, Hossein, FARZAN, Abdonaser, MOHAMMADI, Hassan Reza, NILIPOUR, Yalda, KHODDAMI, Maliheh, JADALI, Farzaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577695/
https://www.ncbi.nlm.nih.gov/pubmed/26401150
_version_ 1782390998203105280
author AGHAYAN GOLKASHANI, Hosein
HATAMI, Hossein
FARZAN, Abdonaser
MOHAMMADI, Hassan Reza
NILIPOUR, Yalda
KHODDAMI, Maliheh
JADALI, Farzaneh
author_facet AGHAYAN GOLKASHANI, Hosein
HATAMI, Hossein
FARZAN, Abdonaser
MOHAMMADI, Hassan Reza
NILIPOUR, Yalda
KHODDAMI, Maliheh
JADALI, Farzaneh
author_sort AGHAYAN GOLKASHANI, Hosein
collection PubMed
description OBJECTIVE: Few studies exist on the demographics and trends of pediatric central nervous system (CNS) tumors in Iran. In this study, we retrospectively reviewed all cases with confirmed CNS tumors admitted to Mofid Pediatric Hospital, Tehran, Iran during the last 18 years. MATERIALS & METHODS: Data on gender, age of diagnosis, pathologic classification and tumor location were extracted from the available medical records. We used the last version of International Classification of Childhood Cancer. RESULT: Overall, 258 (81.9%) brain tumors and 57 (18.1%) spinal tumors were identified. Our subjects comprised of 147 (46.7%) female and 168 (53.3%) male children. More male dominancy was observed in brain tumors with a male to female ratio of 1.2 compared with 1.03 of spinal tumors. Malignant CNS tumors were most common in 1-4 yr age group. The four most common brain tumors in our subjects were astrocytomas, medulloblastoma, ependymoma and craniopharyngioma. Overall, 53.1% of the brain tumors were supratentorial. Gliomas, PNET and neuroblastma were the most frequent primary spinal tumors in our study. We observed an increasing trend for both brain and spinal tumors that was moreremarkable in the last 5 years. CONCLUSION: Our results are comparable with similar single center studies on CNS tumors during childhood. The observed disparities could be attributed to the single center nature of our study and geographical, environmental and racial variations in pediatric CNS tumors. The increasing trend of both brain and spinal tumors could warrant further investigations at provincial and national levels to investigate probable contributing environmental risk factors.
format Online
Article
Text
id pubmed-4577695
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Shahid Beheshti University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-45776952015-10-01 Tumors of the Central Nervous System: An 18-Year Retrospective Review in a Tertiary Pediatric Referral Center AGHAYAN GOLKASHANI, Hosein HATAMI, Hossein FARZAN, Abdonaser MOHAMMADI, Hassan Reza NILIPOUR, Yalda KHODDAMI, Maliheh JADALI, Farzaneh Iran J Child Neurol Original Article OBJECTIVE: Few studies exist on the demographics and trends of pediatric central nervous system (CNS) tumors in Iran. In this study, we retrospectively reviewed all cases with confirmed CNS tumors admitted to Mofid Pediatric Hospital, Tehran, Iran during the last 18 years. MATERIALS & METHODS: Data on gender, age of diagnosis, pathologic classification and tumor location were extracted from the available medical records. We used the last version of International Classification of Childhood Cancer. RESULT: Overall, 258 (81.9%) brain tumors and 57 (18.1%) spinal tumors were identified. Our subjects comprised of 147 (46.7%) female and 168 (53.3%) male children. More male dominancy was observed in brain tumors with a male to female ratio of 1.2 compared with 1.03 of spinal tumors. Malignant CNS tumors were most common in 1-4 yr age group. The four most common brain tumors in our subjects were astrocytomas, medulloblastoma, ependymoma and craniopharyngioma. Overall, 53.1% of the brain tumors were supratentorial. Gliomas, PNET and neuroblastma were the most frequent primary spinal tumors in our study. We observed an increasing trend for both brain and spinal tumors that was moreremarkable in the last 5 years. CONCLUSION: Our results are comparable with similar single center studies on CNS tumors during childhood. The observed disparities could be attributed to the single center nature of our study and geographical, environmental and racial variations in pediatric CNS tumors. The increasing trend of both brain and spinal tumors could warrant further investigations at provincial and national levels to investigate probable contributing environmental risk factors. Shahid Beheshti University of Medical Sciences 2015 /pmc/articles/PMC4577695/ /pubmed/26401150 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
AGHAYAN GOLKASHANI, Hosein
HATAMI, Hossein
FARZAN, Abdonaser
MOHAMMADI, Hassan Reza
NILIPOUR, Yalda
KHODDAMI, Maliheh
JADALI, Farzaneh
Tumors of the Central Nervous System: An 18-Year Retrospective Review in a Tertiary Pediatric Referral Center
title Tumors of the Central Nervous System: An 18-Year Retrospective Review in a Tertiary Pediatric Referral Center
title_full Tumors of the Central Nervous System: An 18-Year Retrospective Review in a Tertiary Pediatric Referral Center
title_fullStr Tumors of the Central Nervous System: An 18-Year Retrospective Review in a Tertiary Pediatric Referral Center
title_full_unstemmed Tumors of the Central Nervous System: An 18-Year Retrospective Review in a Tertiary Pediatric Referral Center
title_short Tumors of the Central Nervous System: An 18-Year Retrospective Review in a Tertiary Pediatric Referral Center
title_sort tumors of the central nervous system: an 18-year retrospective review in a tertiary pediatric referral center
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577695/
https://www.ncbi.nlm.nih.gov/pubmed/26401150
work_keys_str_mv AT aghayangolkashanihosein tumorsofthecentralnervoussysteman18yearretrospectivereviewinatertiarypediatricreferralcenter
AT hatamihossein tumorsofthecentralnervoussysteman18yearretrospectivereviewinatertiarypediatricreferralcenter
AT farzanabdonaser tumorsofthecentralnervoussysteman18yearretrospectivereviewinatertiarypediatricreferralcenter
AT mohammadihassanreza tumorsofthecentralnervoussysteman18yearretrospectivereviewinatertiarypediatricreferralcenter
AT nilipouryalda tumorsofthecentralnervoussysteman18yearretrospectivereviewinatertiarypediatricreferralcenter
AT khoddamimaliheh tumorsofthecentralnervoussysteman18yearretrospectivereviewinatertiarypediatricreferralcenter
AT jadalifarzaneh tumorsofthecentralnervoussysteman18yearretrospectivereviewinatertiarypediatricreferralcenter