NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1

The NF-κB pathway is central to the regulation of inflammation. Here, we demonstrate that the low-output nitric oxide (NO) synthase 1 (NOS1 or nNOS) plays a critical role in the inflammatory response by promoting the activity of NF-κB. Specifically, NOS1-derived NO production in macrophages leads to...

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Detalles Bibliográficos
Autores principales: Baig, Mirza Saqib, Zaichick, Sofia V., Mao, Mao, de Abreu, Andre L., Bakhshi, Farnaz R., Hart, Peter C., Saqib, Uzma, Deng, Jing, Chatterjee, Saurabh, Block, Michelle L., Vogel, Stephen M., Malik, Asrar B., Consolaro, Marcia E.L., Christman, John W., Minshall, Richard D., Gantner, Benjamin N., Bonini, Marcelo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577833/
https://www.ncbi.nlm.nih.gov/pubmed/26324446
http://dx.doi.org/10.1084/jem.20140654

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