A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis

Although IL-17 is emerging as an important cytokine in cancer promotion and progression, the underlining molecular mechanism remains unclear. Previous studies suggest that IL-17 (IL-17A) sustains a chronic inflammatory microenvironment that favors tumor formation. Here we report a novel IL-17–mediat...

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Detalles Bibliográficos
Autores principales: Wu, Ling, Chen, Xing, Zhao, Junjie, Martin, Bradley, Zepp, Jarod A., Ko, Jennifer S., Gu, Chunfang, Cai, Gang, Ouyang, Wenjun, Sen, Ganes, Stark, George R., Su, Bing, Vines, Charlotte M., Tournier, Cathy, Hamilton, Thomas A., Vidimos, Allison, Gastman, Brian, Liu, Caini, Li, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577838/
https://www.ncbi.nlm.nih.gov/pubmed/26347473
http://dx.doi.org/10.1084/jem.20150204

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