Cargando…

NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ–IL-27 axis

IFN-γ is a pathogenic cytokine involved in inflammation. Paradoxically, its deficiency exacerbates experimental autoimmune encephalomyelitis, uveitis, and arthritis. Here, we demonstrate using IFN-γ(−/−) mice repleted with IFN-γ(+/+) NK cells that innate production of IFN-γ from NK cells is necessar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chong, Wai Po, van Panhuys, Nicholas, Chen, Jun, Silver, Phyllis B., Jittayasothorn, Yingyos, Mattapallil, Mary J., Germain, Ronald N., Caspi, Rachel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577839/ https://www.ncbi.nlm.nih.gov/pubmed/26347474 http://dx.doi.org/10.1084/jem.20141678

Ejemplares similares

The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24
por: Chong, Wai Po, et al.
Publicado: (2020)

NK-DC Crosstalk in Immunity to Microbial Infection
por: Thomas, Rony, et al.
Publicado: (2016)

A novel role for lipoxin A(4) in driving a lymph node–eye axis that controls autoimmunity to the neuroretina
por: Wei, Jessica, et al.
Publicado: (2020)

The Memories of NK Cells: Innate-Adaptive Immune Intrinsic Crosstalk
por: Gabrielli, Sara, et al.
Publicado: (2016)

Enterocyte–innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium
por: Gullicksrud, Jodi A., et al.
Publicado: (2022)

Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-γ
por: Oth, Tammy, et al.
Publicado: (2018)

Cyclic dinucleotides (CDNs) anti-tumors response by activating DC and NK cell crosstalk
por: Fu, Juan, et al.
Publicado: (2014)

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk
por: Chinnery, Fay, et al.
Publicado: (2012)

Too Much of a Good Thing: Extended Duration of Gut Microbiota Depletion Reverses Protection From Experimental Autoimmune Uveitis
por: Salvador, Ryan, et al.
Publicado: (2023)

TCR Signal Strength Alters T–DC Activation and Interaction Times and Directs the Outcome of Differentiation
por: van Panhuys, Nicholas
Publicado: (2016)

Autopathogenic T Helper Cell Type 1 (Th1) and Protective Th2 Clones Differ in Their Recognition of the Autoantigenic Peptide of Myelin Proteolipid Protein
por: Das, Mercy Prabhu, et al.
Publicado: (1997)

IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure
por: Li, Zhong-Yin, et al.
Publicado: (2015)

IL-27 Driven Upregulation of Surface HLA-E Expression on Monocytes Inhibits IFN-γ Release by Autologous NK Cells
por: Morandi, Fabio, et al.
Publicado: (2014)

Innate Cytokine Induced Early Release of IFNγ and CC Chemokines from Hypoxic Human NK Cells Is Independent of Glucose
por: Velásquez, Sonia Y., et al.
Publicado: (2020)

Lipopolysaccharide induces IFN-γ production in human NK cells
por: Kanevskiy, Leonid M., et al.
Publicado: (2013)

CD160 is essential for NK-mediated IFN-γ production
por: Tu, Tony C., et al.
Publicado: (2015)

T-bet-dependent ILC1- and NK cell-derived IFN-γ mediates cDC1-dependent host resistance against Toxoplasma gondii
por: López-Yglesias, Américo H., et al.
Publicado: (2021)

Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis
por: Kang, Minkyung, et al.
Publicado: (2020)

Intermediate monocytes induced by IFN-γ inhibit cancer metastasis by promoting NK cell activation through FOXO1 and interleukin-27
por: Wang, Rikang, et al.
Publicado: (2022)

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii
por: Clark, Joseph T, et al.
Publicado: (2021)

Identification of IFN-γ-producing innate B cells
por: Bao, Yan, et al.
Publicado: (2014)

Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity
por: Noubade, Rajkumar, et al.
Publicado: (2019)

Innate IFN-γ-Producing Cells in the Spleen of Mice Early after Listeria monocytogenes Infection: Importance of Microenvironment of the Cells Involved in the Production of Innate IFN-γ
por: Kubota, Koichi, et al.
Publicado: (2011)

NK-cell fratricide: Dynamic crosstalk between NK and cancer cells
por: Nakamura, Kyohei, et al.
Publicado: (2013)

IL-10 Suppression of NK/DC Crosstalk Leads to Poor Priming of MCMV-Specific CD4 T Cells and Prolonged MCMV Persistence
por: Mandaric, Sanja, et al.
Publicado: (2012)

Genome-Wide CRISPR Screen Reveals Cancer Cell Resistance to NK Cells Induced by NK-Derived IFN-γ
por: Zhuang, Xiaoxuan, et al.
Publicado: (2019)

Molecular Characteristics and Efficacy of 16D10 siRNAs in Inhibiting Root-Knot Nematode Infection in Transgenic Grape Hairy Roots
por: Yang, Yingzhen, et al.
Publicado: (2013)

Innate-Adaptive Immune Crosstalk
por: Shanker, Anil, et al.
Publicado: (2015)

IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella
por: Lin, Qiubin, et al.
Publicado: (2021)

Comparison of morphology, phenotypes and function between cultured human IL-4-DC and IFN-DC
por: Jin, Zhiliang, et al.
Publicado: (2017)

HMGB1 Is Involved in IFN-α Production and TRAIL Expression by HIV-1-Exposed Plasmacytoid Dendritic Cells: Impact of the Crosstalk with NK Cells
por: Saïdi, Héla, et al.
Publicado: (2016)

Essential Role of NK Cells in IgG Therapy for Experimental Autoimmune Encephalomyelitis
por: Chong, Wai Po, et al.
Publicado: (2013)

IFN type III: in vivo NK cell response
por: Souza-Fonseca-Guimaraes, Fernando, et al.
Publicado: (2015)

Messenger RNA exchange between scions and rootstocks in grafted grapevines
por: Yang, Yingzhen, et al.
Publicado: (2015)

Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege
por: Yu, Cheng-Rong, et al.
Publicado: (2022)

Recombinant LPG3 Stimulates IFN-Γ and TNF-A Secretion by Human NK Cells
por: RASOLZADEH, Sanaz, et al.
Publicado: (2015)

Recombinant LPG3 Stimulates IFN-Γ and TNF-Α Secretion by Human NK Cells
por: RASOLZADEH, Sanaz, et al.
Publicado: (2015)

Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster
por: Kim, Choon Kwan, et al.
Publicado: (2018)

Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ
por: Widdrington, John D., et al.
Publicado: (2017)

The Regulation of Immune Responses by DC Derived Type I IFN
por: Ng, Dennis, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_mkh60ptoia0r1r66t7tpi7vml2