Cargando…

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of T cell responses. Germline Ctla4 deficiency is lethal, making investigation of the function of CTLA-4 on mature T cells challenging. To elucidate the function of CTLA-4 on mature T cells, we have conditionally ablated Ct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paterson, Alison M., Lovitch, Scott B., Sage, Peter T., Juneja, Vikram R., Lee, Youjin, Trombley, Justin D., Arancibia-Cárcamo, Carolina V., Sobel, Raymond A., Rudensky, Alexander Y., Kuchroo, Vijay K., Freeman, Gordon J., Sharpe, Arlene H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577848/ https://www.ncbi.nlm.nih.gov/pubmed/26371185 http://dx.doi.org/10.1084/jem.20141030

Ejemplares similares

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis
por: Chang, Tammy T., et al.
Publicado: (1999)

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses
por: Clement, Rachel L., et al.
Publicado: (2019)

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance
por: Tan, Catherine L., et al.
Publicado: (2020)

Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis
por: Bettelli, Estelle, et al.
Publicado: (2004)

Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis
por: Bettelli, Estelle, et al.
Publicado: (2003)

Defining the functional states of Th17 cells
por: Lee, Youjin, et al.
Publicado: (2015)

Tim-2 regulates T helper type 2 responses and autoimmunity
por: Chakravarti, Sumone, et al.
Publicado: (2005)

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
por: Francisco, Loise M., et al.
Publicado: (2009)

CTLA-4 and Autoimmunity: New Twists in the Tale
por: Walker, Lucy S.K.
Publicado: (2015)

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program
por: Hou, Shenda, et al.
Publicado: (2019)

CTLA-4: a negative regulator of autoimmune disease
Publicado: (1996)

A case of autoimmune enteropathy with CTLA4 haploinsufficiency
por: Miyazaki, Haruka, et al.
Publicado: (2022)

CTLA-4 Insufficiency due to a Novel CTLA-4 Deletion, Identified through Copy Number Variation Analysis
por: Olfe, Lisa, et al.
Publicado: (2022)

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)
por: Mandelbrot, Didier A., et al.
Publicado: (1999)

CTLA-4 as a genetic determinant in autoimmune Addison’s disease
por: Wolff, A S B, et al.
Publicado: (2015)

Current understanding of CTLA-4: from mechanism to autoimmune diseases
por: Hossen, Md Munnaf, et al.
Publicado: (2023)

T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity
por: Sagan, Sharon A., et al.
Publicado: (2023)

The soluble CTLA-4 receptor and its role in autoimmune diseases: an update
por: Saverino, Daniele, et al.
Publicado: (2010)

CTLA4-Ig treatment prevents murine experimental autoimmune encephalomyelitis
por: Cross, A.H., et al.
Publicado: (1994)

Induction and molecular signature of pathogenic T(H)17 cells
por: Lee, Youjin, et al.
Publicado: (2012)

The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity
por: Schnell, Alexandra, et al.
Publicado: (2020)

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity
por: Juneja, Vikram R., et al.
Publicado: (2017)

Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen
por: Carrizosa, A.M., et al.
Publicado: (1998)

Autoimmune manifestations of CTLA-4 haploinsufficiency in two patients of Southeast Asian ethnicity
por: Lim, Xin Rong, et al.
Publicado: (2023)

Latent autoimmune diabetes of adulthood: case report
por: Page, Cristen P., et al.
Publicado: (2017)

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes
por: Lühder, Fred, et al.
Publicado: (1998)

CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population
por: Thye, Thorsten, et al.
Publicado: (2009)

Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis
por: Jolly, Elaine C., et al.
Publicado: (2009)

Fatal CTLA‐4 heterozygosity with autoimmunity and recurrent infections: a de novo mutation
por: Moraes‐Fontes, Maria Francisca, et al.
Publicado: (2017)

SUN-332 Autoimmune Endocrinopathies Associated with CTLA-4 Inhibitors: A Meta-Analysis
por: Darapu, Hima, et al.
Publicado: (2019)

CTLA4-Linked Autoimmunity in the Pathogenesis of Endometriosis and Related Infertility: A Systematic Review
por: Mikuš, Mislav, et al.
Publicado: (2022)

The Soluble Form of CTLA-4 from Serum of Patients with Autoimmune Diseases Regulates T-Cell Responses
por: Simone, Rita, et al.
Publicado: (2014)

The node of Ranvier in CNS pathology
por: Arancibia-Carcamo, I. Lorena, et al.
Publicado: (2014)

Innate Lymphoid Cells in Intestinal Inflammation
por: Geremia, Alessandra, et al.
Publicado: (2017)

Intestine-Specific NHE3 Deletion in Adulthood Causes Microbial Dysbiosis
por: Xue, Jianxiang, et al.
Publicado: (2022)

SUN-123 An Unusual Case of How Statin-Induced Diabetes Revealed Underlying Latent Autoimmune Diabetes of Adulthood
por: Mai, Raymond, et al.
Publicado: (2019)

Bladder exstrophy in adulthood
por: Nerli, R. B., et al.
Publicado: (2008)

CTLA-4 gene polymorphisms and their influence on predisposition to autoimmune thyroid diseases (Graves’ disease and Hashimoto's thyroiditis)
por: Pastuszak-Lewandoska, Dorota, et al.
Publicado: (2012)

Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1
por: Kong, Yi-chi M., et al.
Publicado: (2014)

Association of Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) and Thyroglobulin (TG) Genetic Variants with Autoimmune Hypothyroidism
por: Patel, Hinal, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_pli2jg5i8eovanmp9ople6vutm