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Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population

BACKGROUND/AIMS: A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean popula...

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Detalles Bibliográficos
Autores principales: Do, Sook Kyung, Yoo, Seung Soo, Choi, Yi Young, Choi, Jin Eun, Jeon, Hyo-Sung, Lee, Won Kee, Lee, Shin Yup, Lee, Jaehee, Cha, Seung Ick, Kim, Chang Ho, Park, Jae Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578038/
https://www.ncbi.nlm.nih.gov/pubmed/26354067
http://dx.doi.org/10.3904/kjim.2015.30.5.719
Descripción
Sumario:BACKGROUND/AIMS: A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean population. METHODS: Ninety-four healthy individuals were enrolled in this study. Relative telomere length of chromosomes from peripheral blood samples was measured using quantitative polymerase chain reaction. RESULTS: Two polymorphisms, rs10936599 of MYNN and rs412658 of ZNF676, were found to be associated w ith telomere length (under dominant model, p = 0.04; under recessive model, p = 0.001). Three polymorphisms, rs2853669, rs7705526, and rs2736108, at the TERT locus were also associated with telomere length (under recessive model, p = 0.01, p = 0.02, and p = 0.01, respectively). The genotypes of the five polymorphisms associated with short telomere length were considered bad genotypes; telomere length was significantly decreased with increasing number of bad genotypes (p= 1.7 × 10(–5)). CONCLUSIONS: We have identified polymorphisms associated with telomere length in a Korean population.