YAP controls retinal stem cell DNA replication timing and genomic stability

The adult frog retina retains a reservoir of active neural stem cells that contribute to continuous eye growth throughout life. We found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in these stem cells. Yap knock-down leads to an accelerated S-phase and an abnormal...

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Detalles Bibliográficos
Autores principales: Cabochette, Pauline, Vega-Lopez, Guillermo, Bitard, Juliette, Parain, Karine, Chemouny, Romain, Masson, Christel, Borday, Caroline, Hedderich, Marie, Henningfeld, Kristine A, Locker, Morgane, Bronchain, Odile, Perron, Muriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578106/
https://www.ncbi.nlm.nih.gov/pubmed/26393999
http://dx.doi.org/10.7554/eLife.08488

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