New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y(2)) isolated from the South China Sea

Three new depsidones, botryorhodines E–G (1–3), and two new isoindolinones, meyeroguillines A and B (7 and 9), along with five known compounds were isolated from an endophytic fungus Meyerozyma guilliermondii, derived from the mangrove plant Kandelia obovata. Their structures were elucidated by 1D a...

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Autores principales: Chen, Senhua, Liu, Zhaoming, Liu, Yayue, Lu, Yongjun, He, Lei, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578337/
https://www.ncbi.nlm.nih.gov/pubmed/26425177
http://dx.doi.org/10.3762/bjoc.11.133
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author Chen, Senhua
Liu, Zhaoming
Liu, Yayue
Lu, Yongjun
He, Lei
She, Zhigang
author_facet Chen, Senhua
Liu, Zhaoming
Liu, Yayue
Lu, Yongjun
He, Lei
She, Zhigang
author_sort Chen, Senhua
collection PubMed
description Three new depsidones, botryorhodines E–G (1–3), and two new isoindolinones, meyeroguillines A and B (7 and 9), along with five known compounds were isolated from an endophytic fungus Meyerozyma guilliermondii, derived from the mangrove plant Kandelia obovata. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry (HREIMS). Compounds 1–6 exhibited strong α-glucosidase inhibitory activity with IC(50) values ranging from 2.1 to 13.3 μM. Moreover, kinetic studies of compounds 2 and 6 showed that both of them were noncompetitive inhibitors of α-glucosidase.
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spelling pubmed-45783372015-09-30 New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y(2)) isolated from the South China Sea Chen, Senhua Liu, Zhaoming Liu, Yayue Lu, Yongjun He, Lei She, Zhigang Beilstein J Org Chem Full Research Paper Three new depsidones, botryorhodines E–G (1–3), and two new isoindolinones, meyeroguillines A and B (7 and 9), along with five known compounds were isolated from an endophytic fungus Meyerozyma guilliermondii, derived from the mangrove plant Kandelia obovata. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry (HREIMS). Compounds 1–6 exhibited strong α-glucosidase inhibitory activity with IC(50) values ranging from 2.1 to 13.3 μM. Moreover, kinetic studies of compounds 2 and 6 showed that both of them were noncompetitive inhibitors of α-glucosidase. Beilstein-Institut 2015-07-16 /pmc/articles/PMC4578337/ /pubmed/26425177 http://dx.doi.org/10.3762/bjoc.11.133 Text en Copyright © 2015, Chen et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Chen, Senhua
Liu, Zhaoming
Liu, Yayue
Lu, Yongjun
He, Lei
She, Zhigang
New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y(2)) isolated from the South China Sea
title New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y(2)) isolated from the South China Sea
title_full New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y(2)) isolated from the South China Sea
title_fullStr New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y(2)) isolated from the South China Sea
title_full_unstemmed New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y(2)) isolated from the South China Sea
title_short New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y(2)) isolated from the South China Sea
title_sort new depsidones and isoindolinones from the mangrove endophytic fungus meyerozyma guilliermondii (hz-y(2)) isolated from the south china sea
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578337/
https://www.ncbi.nlm.nih.gov/pubmed/26425177
http://dx.doi.org/10.3762/bjoc.11.133
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