Deproto-metallation of N-arylated pyrroles and indoles using a mixed lithium–zinc base and regioselectivity-computed CH acidity relationship

The synthesis of N-arylated pyrroles and indoles is documented, as well as their functionalization by deprotonative metallation using the base in situ prepared from LiTMP and ZnCl(2)·TMEDA (1/3 equiv). With N-phenylpyrrole and -indole, the reactions were carried out in hexane containing TMEDA which...

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Detalles Bibliográficos
Autores principales: Messaoud, Mohamed Yacine Ameur, Bentabed-Ababsa, Ghenia, Hedidi, Madani, Derdour, Aïcha, Chevallier, Floris, Halauko, Yury S, Ivashkevich, Oleg A, Matulis, Vadim E, Picot, Laurent, Thiéry, Valérie, Roisnel, Thierry, Dorcet, Vincent, Mongin, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578368/
https://www.ncbi.nlm.nih.gov/pubmed/26425204
http://dx.doi.org/10.3762/bjoc.11.160

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