The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine

A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions.

Detalles Bibliográficos
Autores principales: Roszkowski, Piotr, Maurin, Jan K, Czarnocki, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578372/
https://www.ncbi.nlm.nih.gov/pubmed/26425208
http://dx.doi.org/10.3762/bjoc.11.164
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author Roszkowski, Piotr
Maurin, Jan K
Czarnocki, Zbigniew
author_facet Roszkowski, Piotr
Maurin, Jan K
Czarnocki, Zbigniew
author_sort Roszkowski, Piotr
collection PubMed
description A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions.
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spelling pubmed-45783722015-09-30 The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine Roszkowski, Piotr Maurin, Jan K Czarnocki, Zbigniew Beilstein J Org Chem Full Research Paper A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions. Beilstein-Institut 2015-08-28 /pmc/articles/PMC4578372/ /pubmed/26425208 http://dx.doi.org/10.3762/bjoc.11.164 Text en Copyright © 2015, Roszkowski et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Roszkowski, Piotr
Maurin, Jan K
Czarnocki, Zbigniew
The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_full The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_fullStr The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_full_unstemmed The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_short The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_sort enantioselective synthesis of (s)-(+)-mianserin and (s)-(+)-epinastine
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578372/
https://www.ncbi.nlm.nih.gov/pubmed/26425208
http://dx.doi.org/10.3762/bjoc.11.164
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