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BTK mutations selectively regulate BTK expression and upregulate monocyte XBP1 mRNA in XLA patients

Mutations in the Bruton agammaglobulinemia tyrosine kinase (BTK) gene are responsible for X-linked agammaglobulinemia (XLA). Unfolded or misfolded proteins can trigger stress pathways in the endoplasmic reticulum (ER), known as unfolded protein response (UPR). The aim was to clarify the involvement...

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Detalles Bibliográficos
Autores principales:	Teocchi, Marcelo A, Domingues Ramalho, Vanessa, Abramczuk, Beatriz M, D'Souza-Li, Lília, Santos Vilela, Maria Marluce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578518/ https://www.ncbi.nlm.nih.gov/pubmed/26417435 http://dx.doi.org/10.1002/iid3.57

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