Resveratrol regulates naïve CD 8(+) T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression

We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol regu...

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Autores principales: Noh, Kyung Tae, Cho, Joon, Chun, Sung Hak, Jang, Jong-Hwa, Cha, Gil Sun, Jung, In Duk, Jang, Dong Deuk, Park, Yeong-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2015
Materias:
Research-Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578568/
https://www.ncbi.nlm.nih.gov/pubmed/25248565
http://dx.doi.org/10.5483/BMBRep.2015.48.5.190
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author Noh, Kyung Tae
Cho, Joon
Chun, Sung Hak
Jang, Jong-Hwa
Cha, Gil Sun
Jung, In Duk
Jang, Dong Deuk
Park, Yeong-Min
author_facet Noh, Kyung Tae
Cho, Joon
Chun, Sung Hak
Jang, Jong-Hwa
Cha, Gil Sun
Jung, In Duk
Jang, Dong Deuk
Park, Yeong-Min
author_sort Noh, Kyung Tae
collection PubMed
description We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol regulates naïve CD8(+) T-cell polarization by modulating GSK-3β activity in IFN-γ-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8(+) T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN-γ-induced TTS expression in a GSK-3β-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation. [BMB Reports 2015; 48(5): 283-288]
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spelling pubmed-45785682015-09-22 Resveratrol regulates naïve CD 8(+) T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression Noh, Kyung Tae Cho, Joon Chun, Sung Hak Jang, Jong-Hwa Cha, Gil Sun Jung, In Duk Jang, Dong Deuk Park, Yeong-Min BMB Rep Research-Article We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol regulates naïve CD8(+) T-cell polarization by modulating GSK-3β activity in IFN-γ-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8(+) T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN-γ-induced TTS expression in a GSK-3β-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation. [BMB Reports 2015; 48(5): 283-288] Korean Society for Biochemistry and Molecular Biology 2015-05 /pmc/articles/PMC4578568/ /pubmed/25248565 http://dx.doi.org/10.5483/BMBRep.2015.48.5.190 Text en Copyright © 2015, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research-Article
Noh, Kyung Tae
Cho, Joon
Chun, Sung Hak
Jang, Jong-Hwa
Cha, Gil Sun
Jung, In Duk
Jang, Dong Deuk
Park, Yeong-Min
Resveratrol regulates naïve CD 8(+) T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
title Resveratrol regulates naïve CD 8(+) T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
title_full Resveratrol regulates naïve CD 8(+) T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
title_fullStr Resveratrol regulates naïve CD 8(+) T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
title_full_unstemmed Resveratrol regulates naïve CD 8(+) T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
title_short Resveratrol regulates naïve CD 8(+) T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression
title_sort resveratrol regulates naïve cd 8(+) t-cell proliferation by upregulating ifn-γ-induced tryptophanyl-trna synthetase expression
topic Research-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578568/
https://www.ncbi.nlm.nih.gov/pubmed/25248565
http://dx.doi.org/10.5483/BMBRep.2015.48.5.190
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