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Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5′ splice site strength

BACKGROUND: Sequential assembly of the human spliceosome on RNA transcripts regulates splicing across the human transcriptome. The core spliceosome component PRPF8 is essential for spliceosome assembly through its participation in ribonucleoprotein (RNP) complexes for splice-site recognition, branch...

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Detalles Bibliográficos
Autores principales:	Wickramasinghe, Vihandha O., Gonzàlez-Porta, Mar, Perera, David, Bartolozzi, Arthur R., Sibley, Christopher R., Hallegger, Martina, Ule, Jernej, Marioni, John C., Venkitaraman, Ashok R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578845/ https://www.ncbi.nlm.nih.gov/pubmed/26392272 http://dx.doi.org/10.1186/s13059-015-0749-3

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