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Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus

BACKGROUND: The aim of the study was to estimate the effect of the accumulation of major life events (MLE) in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction between childhood and adu...

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Autores principales: Masters Pedersen, Jolene, Hulvej Rod, Naja, Andersen, Ingelise, Lange, Theis, Poulsen, Gry, Prescott, Eva, Lund, Rikke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578856/
https://www.ncbi.nlm.nih.gov/pubmed/26394040
http://dx.doi.org/10.1371/journal.pone.0138654
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author Masters Pedersen, Jolene
Hulvej Rod, Naja
Andersen, Ingelise
Lange, Theis
Poulsen, Gry
Prescott, Eva
Lund, Rikke
author_facet Masters Pedersen, Jolene
Hulvej Rod, Naja
Andersen, Ingelise
Lange, Theis
Poulsen, Gry
Prescott, Eva
Lund, Rikke
author_sort Masters Pedersen, Jolene
collection PubMed
description BACKGROUND: The aim of the study was to estimate the effect of the accumulation of major life events (MLE) in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction between childhood and adult MLE and to investigate modification of these associations by educational attainment. METHODS: The study was based on 4,761 participants from the Copenhagen City Heart Study free of diabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or more events. Multivariate logistic regression models adjusted for age, sex, education and family history of diabetes were used to estimate the association between MLE and T2DM. RESULTS: In childhood, experiencing 3 or more MLE was associated with a 69% higher risk of developing T2DM (Odds Ratio (OR) 1.69; 95% Confidence Interval (CI) 1.60, 3.27). The accumulation of MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associated with risk of T2DM in a dose response manner. There was no evidence that experiencing MLE in both childhood and adult life was more strongly associated with T2DM than experiencing events at only one time point. There was some evidence that being simultaneously exposed to childhood MLE and short education (OR 2.28; 95% C.I. 1.45, 3.59) and work MLE and short education (OR 2.86; 95% C.I. 1.62, 5.03) was associated with higher risk of T2DM, as the joint effects were greater than the sum of their individual effects. CONCLUSIONS: Findings from this study suggest that the accumulation of MLE in childhood, private adult life and work life, respectively, are risk factors for developing T2DM.
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spelling pubmed-45788562015-10-01 Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus Masters Pedersen, Jolene Hulvej Rod, Naja Andersen, Ingelise Lange, Theis Poulsen, Gry Prescott, Eva Lund, Rikke PLoS One Research Article BACKGROUND: The aim of the study was to estimate the effect of the accumulation of major life events (MLE) in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction between childhood and adult MLE and to investigate modification of these associations by educational attainment. METHODS: The study was based on 4,761 participants from the Copenhagen City Heart Study free of diabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or more events. Multivariate logistic regression models adjusted for age, sex, education and family history of diabetes were used to estimate the association between MLE and T2DM. RESULTS: In childhood, experiencing 3 or more MLE was associated with a 69% higher risk of developing T2DM (Odds Ratio (OR) 1.69; 95% Confidence Interval (CI) 1.60, 3.27). The accumulation of MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associated with risk of T2DM in a dose response manner. There was no evidence that experiencing MLE in both childhood and adult life was more strongly associated with T2DM than experiencing events at only one time point. There was some evidence that being simultaneously exposed to childhood MLE and short education (OR 2.28; 95% C.I. 1.45, 3.59) and work MLE and short education (OR 2.86; 95% C.I. 1.62, 5.03) was associated with higher risk of T2DM, as the joint effects were greater than the sum of their individual effects. CONCLUSIONS: Findings from this study suggest that the accumulation of MLE in childhood, private adult life and work life, respectively, are risk factors for developing T2DM. Public Library of Science 2015-09-22 /pmc/articles/PMC4578856/ /pubmed/26394040 http://dx.doi.org/10.1371/journal.pone.0138654 Text en © 2015 Masters Pedersen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Masters Pedersen, Jolene
Hulvej Rod, Naja
Andersen, Ingelise
Lange, Theis
Poulsen, Gry
Prescott, Eva
Lund, Rikke
Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus
title Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus
title_full Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus
title_fullStr Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus
title_full_unstemmed Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus
title_short Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus
title_sort accumulation of major life events in childhood and adult life and risk of type 2 diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578856/
https://www.ncbi.nlm.nih.gov/pubmed/26394040
http://dx.doi.org/10.1371/journal.pone.0138654
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