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Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus
BACKGROUND: The aim of the study was to estimate the effect of the accumulation of major life events (MLE) in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction between childhood and adu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578856/ https://www.ncbi.nlm.nih.gov/pubmed/26394040 http://dx.doi.org/10.1371/journal.pone.0138654 |
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author | Masters Pedersen, Jolene Hulvej Rod, Naja Andersen, Ingelise Lange, Theis Poulsen, Gry Prescott, Eva Lund, Rikke |
author_facet | Masters Pedersen, Jolene Hulvej Rod, Naja Andersen, Ingelise Lange, Theis Poulsen, Gry Prescott, Eva Lund, Rikke |
author_sort | Masters Pedersen, Jolene |
collection | PubMed |
description | BACKGROUND: The aim of the study was to estimate the effect of the accumulation of major life events (MLE) in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction between childhood and adult MLE and to investigate modification of these associations by educational attainment. METHODS: The study was based on 4,761 participants from the Copenhagen City Heart Study free of diabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or more events. Multivariate logistic regression models adjusted for age, sex, education and family history of diabetes were used to estimate the association between MLE and T2DM. RESULTS: In childhood, experiencing 3 or more MLE was associated with a 69% higher risk of developing T2DM (Odds Ratio (OR) 1.69; 95% Confidence Interval (CI) 1.60, 3.27). The accumulation of MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associated with risk of T2DM in a dose response manner. There was no evidence that experiencing MLE in both childhood and adult life was more strongly associated with T2DM than experiencing events at only one time point. There was some evidence that being simultaneously exposed to childhood MLE and short education (OR 2.28; 95% C.I. 1.45, 3.59) and work MLE and short education (OR 2.86; 95% C.I. 1.62, 5.03) was associated with higher risk of T2DM, as the joint effects were greater than the sum of their individual effects. CONCLUSIONS: Findings from this study suggest that the accumulation of MLE in childhood, private adult life and work life, respectively, are risk factors for developing T2DM. |
format | Online Article Text |
id | pubmed-4578856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45788562015-10-01 Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus Masters Pedersen, Jolene Hulvej Rod, Naja Andersen, Ingelise Lange, Theis Poulsen, Gry Prescott, Eva Lund, Rikke PLoS One Research Article BACKGROUND: The aim of the study was to estimate the effect of the accumulation of major life events (MLE) in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction between childhood and adult MLE and to investigate modification of these associations by educational attainment. METHODS: The study was based on 4,761 participants from the Copenhagen City Heart Study free of diabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or more events. Multivariate logistic regression models adjusted for age, sex, education and family history of diabetes were used to estimate the association between MLE and T2DM. RESULTS: In childhood, experiencing 3 or more MLE was associated with a 69% higher risk of developing T2DM (Odds Ratio (OR) 1.69; 95% Confidence Interval (CI) 1.60, 3.27). The accumulation of MLE in adult private (p-trend = 0.016) and work life (p-trend = 0.049) was associated with risk of T2DM in a dose response manner. There was no evidence that experiencing MLE in both childhood and adult life was more strongly associated with T2DM than experiencing events at only one time point. There was some evidence that being simultaneously exposed to childhood MLE and short education (OR 2.28; 95% C.I. 1.45, 3.59) and work MLE and short education (OR 2.86; 95% C.I. 1.62, 5.03) was associated with higher risk of T2DM, as the joint effects were greater than the sum of their individual effects. CONCLUSIONS: Findings from this study suggest that the accumulation of MLE in childhood, private adult life and work life, respectively, are risk factors for developing T2DM. Public Library of Science 2015-09-22 /pmc/articles/PMC4578856/ /pubmed/26394040 http://dx.doi.org/10.1371/journal.pone.0138654 Text en © 2015 Masters Pedersen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Masters Pedersen, Jolene Hulvej Rod, Naja Andersen, Ingelise Lange, Theis Poulsen, Gry Prescott, Eva Lund, Rikke Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus |
title | Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus |
title_full | Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus |
title_fullStr | Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus |
title_full_unstemmed | Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus |
title_short | Accumulation of Major Life Events in Childhood and Adult Life and Risk of Type 2 Diabetes Mellitus |
title_sort | accumulation of major life events in childhood and adult life and risk of type 2 diabetes mellitus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578856/ https://www.ncbi.nlm.nih.gov/pubmed/26394040 http://dx.doi.org/10.1371/journal.pone.0138654 |
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