Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

The cytokine receptor activator of nuclear factor kappa B ligand (RANKL), encoded by the Tnfsf11 gene, is essential for osteoclastogenesis and previous studies have shown that deletion of the Tnfsf11 gene using a Dmp1-Cre transgene reduces osteoclast formation in cancellous bone by more than 70%. Ho...

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Detalles Bibliográficos
Autores principales: Xiong, Jinhu, Piemontese, Marilina, Onal, Melda, Campbell, Josh, Goellner, Joseph J., Dusevich, Vladimir, Bonewald, Lynda, Manolagas, Stavros C., O’Brien, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578942/
https://www.ncbi.nlm.nih.gov/pubmed/26393791
http://dx.doi.org/10.1371/journal.pone.0138189

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