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APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders

Purpose. To examine the associations among age, Apolipoprotein E (APOE) genotype, metabolic changes in the hippocampus detected by 2D (1)H magnetic resonance spectroscopy (MRS), and neuropsychological measures of cognition in non-demented elders. Materials and Methods. We studied a cohort of 16 cogn...

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Autores principales: Yin, Zhenyu, Wu, Wenbo, Liu, Renyuan, Liang, Xue, Yu, Tingting, Chen, Xiaoling, Feng, Jie, Guo, Aibin, Xie, Yu, Yang, Haiyan, Huang, Mingmin, Tian, Chuanshuai, Zhang, Bing, Xu, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579016/
https://www.ncbi.nlm.nih.gov/pubmed/26401443
http://dx.doi.org/10.7717/peerj.1202
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author Yin, Zhenyu
Wu, Wenbo
Liu, Renyuan
Liang, Xue
Yu, Tingting
Chen, Xiaoling
Feng, Jie
Guo, Aibin
Xie, Yu
Yang, Haiyan
Huang, Mingmin
Tian, Chuanshuai
Zhang, Bing
Xu, Yun
author_facet Yin, Zhenyu
Wu, Wenbo
Liu, Renyuan
Liang, Xue
Yu, Tingting
Chen, Xiaoling
Feng, Jie
Guo, Aibin
Xie, Yu
Yang, Haiyan
Huang, Mingmin
Tian, Chuanshuai
Zhang, Bing
Xu, Yun
author_sort Yin, Zhenyu
collection PubMed
description Purpose. To examine the associations among age, Apolipoprotein E (APOE) genotype, metabolic changes in the hippocampus detected by 2D (1)H magnetic resonance spectroscopy (MRS), and neuropsychological measures of cognition in non-demented elders. Materials and Methods. We studied a cohort of 16 cognitively normal controls (CN) and 11 amnestic mild cognitive impairment (aMCI) patients between 66 and 88 years old who were genotyped for APOE genetic polymorphism. Measurements of 2D(1)H-MRS metabolites were obtained in the hippocampus region. Adjusting by age among all subjects, the association between metabolic changes and cognitive function was measured by Spearman partial rank-order correlation. The effect of APOE status was measured by separating the subjects into APOE genotype subgroups, including the APOEε4 carriers and APOEε4 non-carriers. Results. In contrast to the CN group matched with age, gender, and education, aMCI patients showed increased myo-inositol (mI)/Creatine (Cr) ratio only in the right hippocampus. No differences were noted on N-acetylaspartate (NAA)/Cr and mI/NAA from bilateral hippocampus, and so was mI/Cr ratio in left hippocampus between aMCI and CN. The mI/Cr ratio from the right hippocampus in non-demented elders was negatively correlated with Montreal Cognitive Assessment (MoCA) scores. Whether ε4 genotype or age was added as a covariate, none of the correlation effects remained significant. Additionally, adjusting for age and APOE genotype together, there was no significant correlation between them. Conclusion. Since the higher mI/Cr from the right hippocampus of the patients with aMCI than those from CN, the mI/Cr could be a more specific predictor of general cognitive function in aMCI patients. There is an association between higher mI/Cr in right hippocampus and worse cognitive function for the non-demented older adults, and the correlation could be modified by APOE status and age. That provided a window on objectively understanding the mechanism between the brain metabolites and the influence factors in non-demented elders.
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spelling pubmed-45790162015-09-23 APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders Yin, Zhenyu Wu, Wenbo Liu, Renyuan Liang, Xue Yu, Tingting Chen, Xiaoling Feng, Jie Guo, Aibin Xie, Yu Yang, Haiyan Huang, Mingmin Tian, Chuanshuai Zhang, Bing Xu, Yun PeerJ Neuroscience Purpose. To examine the associations among age, Apolipoprotein E (APOE) genotype, metabolic changes in the hippocampus detected by 2D (1)H magnetic resonance spectroscopy (MRS), and neuropsychological measures of cognition in non-demented elders. Materials and Methods. We studied a cohort of 16 cognitively normal controls (CN) and 11 amnestic mild cognitive impairment (aMCI) patients between 66 and 88 years old who were genotyped for APOE genetic polymorphism. Measurements of 2D(1)H-MRS metabolites were obtained in the hippocampus region. Adjusting by age among all subjects, the association between metabolic changes and cognitive function was measured by Spearman partial rank-order correlation. The effect of APOE status was measured by separating the subjects into APOE genotype subgroups, including the APOEε4 carriers and APOEε4 non-carriers. Results. In contrast to the CN group matched with age, gender, and education, aMCI patients showed increased myo-inositol (mI)/Creatine (Cr) ratio only in the right hippocampus. No differences were noted on N-acetylaspartate (NAA)/Cr and mI/NAA from bilateral hippocampus, and so was mI/Cr ratio in left hippocampus between aMCI and CN. The mI/Cr ratio from the right hippocampus in non-demented elders was negatively correlated with Montreal Cognitive Assessment (MoCA) scores. Whether ε4 genotype or age was added as a covariate, none of the correlation effects remained significant. Additionally, adjusting for age and APOE genotype together, there was no significant correlation between them. Conclusion. Since the higher mI/Cr from the right hippocampus of the patients with aMCI than those from CN, the mI/Cr could be a more specific predictor of general cognitive function in aMCI patients. There is an association between higher mI/Cr in right hippocampus and worse cognitive function for the non-demented older adults, and the correlation could be modified by APOE status and age. That provided a window on objectively understanding the mechanism between the brain metabolites and the influence factors in non-demented elders. PeerJ Inc. 2015-09-17 /pmc/articles/PMC4579016/ /pubmed/26401443 http://dx.doi.org/10.7717/peerj.1202 Text en © 2015 Yin et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Neuroscience
Yin, Zhenyu
Wu, Wenbo
Liu, Renyuan
Liang, Xue
Yu, Tingting
Chen, Xiaoling
Feng, Jie
Guo, Aibin
Xie, Yu
Yang, Haiyan
Huang, Mingmin
Tian, Chuanshuai
Zhang, Bing
Xu, Yun
APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders
title APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders
title_full APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders
title_fullStr APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders
title_full_unstemmed APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders
title_short APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders
title_sort apoe genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2d (1)h-mrs in non-demented elders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579016/
https://www.ncbi.nlm.nih.gov/pubmed/26401443
http://dx.doi.org/10.7717/peerj.1202
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