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Validation of the RRE-90 Scale to Predict Stroke Risk after Transient Symptoms with Infarction: A Prospective Cohort Study

BACKGROUND AND PURPOSE: The risk of stroke after a transient ischemic attack (TIA) for patients with a positive diffusion-weighted image (DWI), i.e., transient symptoms with infarction (TSI), is much higher than for those with a negative DWI. The aim of this study was to validate the predictive valu...

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Detalles Bibliográficos
Autores principales: Song, Bo, Pei, Lulu, Fang, Hui, Zhao, Lu, Gao, Yuan, Wang, Yuanyuan, Tan, Song, Xu, Yuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579076/
https://www.ncbi.nlm.nih.gov/pubmed/26394400
http://dx.doi.org/10.1371/journal.pone.0137425
Descripción
Sumario:BACKGROUND AND PURPOSE: The risk of stroke after a transient ischemic attack (TIA) for patients with a positive diffusion-weighted image (DWI), i.e., transient symptoms with infarction (TSI), is much higher than for those with a negative DWI. The aim of this study was to validate the predictive value of a web-based recurrence risk estimator (RRE; http://www.nmr.mgh.harvard.edu/RRE/) of TSI. METHODS: Data from the prospective hospital-based TIA database of the First Affiliated Hospital of Zhengzhou University were analyzed. The RRE and ABCD(2) scores were calculated within 7 days of symptom onset. The predictive outcome was ischemic stroke occurrence at 90 days. The receiver-operating characteristics curves were plotted, and the predictive value of the two models was assessed by computing the C statistics. RESULTS: A total of 221 eligible patients were prospectively enrolled, of whom 46 (20.81%) experienced a stroke within 90 days. The 90-day stroke risk in high-risk TSI patients (RRE ≥4) was 3.406-fold greater than in those at low risk (P <0.001). The C statistic of RRE (0.681; 95% confidence interval [CI], 0.592–0.771) was statistically higher than that of ABCD(2) score (0.546; 95% CI, 0.454–0.638; Z = 2.115; P = 0.0344) at 90 days. CONCLUSION: The RRE score had a higher predictive value than the ABCD(2) score for assessing the 90-day risk of stroke after TSI.