A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to...

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Detalles Bibliográficos
Autores principales: Mao, Longfei, Nicolae, Averina, Oliveira, Miguel A.P., He, Feng, Hachi, Siham, Fleming, Ronan M.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2015
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579274/
https://www.ncbi.nlm.nih.gov/pubmed/26504511
http://dx.doi.org/10.1016/j.csbj.2015.08.002
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author Mao, Longfei
Nicolae, Averina
Oliveira, Miguel A.P.
He, Feng
Hachi, Siham
Fleming, Ronan M.T.
author_facet Mao, Longfei
Nicolae, Averina
Oliveira, Miguel A.P.
He, Feng
Hachi, Siham
Fleming, Ronan M.T.
author_sort Mao, Longfei
collection PubMed
description One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease.
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spelling pubmed-45792742015-10-26 A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease Mao, Longfei Nicolae, Averina Oliveira, Miguel A.P. He, Feng Hachi, Siham Fleming, Ronan M.T. Comput Struct Biotechnol J Mini Review One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease. Research Network of Computational and Structural Biotechnology 2015-09-02 /pmc/articles/PMC4579274/ /pubmed/26504511 http://dx.doi.org/10.1016/j.csbj.2015.08.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Mini Review
Mao, Longfei
Nicolae, Averina
Oliveira, Miguel A.P.
He, Feng
Hachi, Siham
Fleming, Ronan M.T.
A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_full A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_fullStr A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_full_unstemmed A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_short A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_sort constraint-based modelling approach to metabolic dysfunction in parkinson's disease
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579274/
https://www.ncbi.nlm.nih.gov/pubmed/26504511
http://dx.doi.org/10.1016/j.csbj.2015.08.002
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