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Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters
BACKGROUND: Parafibromin is a recently defined tumor suppressor gene. The aim of our study was to determine the relationships of parafibromin expression in urothelial carcinomas (UCs) with prognostic parameters and to evaluate the use of parafibromin as a potential marker of UC. METHODS: Parafibromi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Pathologists and the Korean Society for Cytopathology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579279/ https://www.ncbi.nlm.nih.gov/pubmed/26395176 http://dx.doi.org/10.4132/jptm.2015.08.10 |
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author | Karaarslan, Serap Yaman, Banu Ozturk, Hakan Kumbaraci, Banu Sarsik |
author_facet | Karaarslan, Serap Yaman, Banu Ozturk, Hakan Kumbaraci, Banu Sarsik |
author_sort | Karaarslan, Serap |
collection | PubMed |
description | BACKGROUND: Parafibromin is a recently defined tumor suppressor gene. The aim of our study was to determine the relationships of parafibromin expression in urothelial carcinomas (UCs) with prognostic parameters and to evaluate the use of parafibromin as a potential marker of UC. METHODS: Parafibromin expression was assessed in 49 UC specimens using immunohistochemistry. The correlations between parafibromin expression and clinical and pathologic parameters were investigated. RESULTS: Of the patients, 42 (85.7%) were male, and the mean age was 69.6 ± 8.2 years (range, 54 to 88 years). Morphologically, the UCs were divided into two groups: papillary (n = 27) and non-papillary (n = 22). There were seven low-grade (14.3%) and 42 high-grade (85.7%) tumors. Parafibromin was negative in 13 tumors (26.5%), partially positive in 19 tumors (38.8%), and positive in 17 tumors (34.7%). Parafibromin expression was more negative in UCs from upper urinary locations (n=17) and with muscularis propria invasion (n=28), which was statistically significant (p = .009 and p = .007, respectively). There was no statistically significant relationship between parafibromin expression and gender, age, tumor grade, survival, or disease-free survival. CONCLUSIONS: We found that UC cases with parafibromin positivity had less of a tendency to show muscularis propria invasion and were more commonly located in the lower urinary system. These results need to be confirmed with studies based on larger case series. |
format | Online Article Text |
id | pubmed-4579279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Society of Pathologists and the Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-45792792015-09-25 Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters Karaarslan, Serap Yaman, Banu Ozturk, Hakan Kumbaraci, Banu Sarsik J Pathol Transl Med Original Article BACKGROUND: Parafibromin is a recently defined tumor suppressor gene. The aim of our study was to determine the relationships of parafibromin expression in urothelial carcinomas (UCs) with prognostic parameters and to evaluate the use of parafibromin as a potential marker of UC. METHODS: Parafibromin expression was assessed in 49 UC specimens using immunohistochemistry. The correlations between parafibromin expression and clinical and pathologic parameters were investigated. RESULTS: Of the patients, 42 (85.7%) were male, and the mean age was 69.6 ± 8.2 years (range, 54 to 88 years). Morphologically, the UCs were divided into two groups: papillary (n = 27) and non-papillary (n = 22). There were seven low-grade (14.3%) and 42 high-grade (85.7%) tumors. Parafibromin was negative in 13 tumors (26.5%), partially positive in 19 tumors (38.8%), and positive in 17 tumors (34.7%). Parafibromin expression was more negative in UCs from upper urinary locations (n=17) and with muscularis propria invasion (n=28), which was statistically significant (p = .009 and p = .007, respectively). There was no statistically significant relationship between parafibromin expression and gender, age, tumor grade, survival, or disease-free survival. CONCLUSIONS: We found that UC cases with parafibromin positivity had less of a tendency to show muscularis propria invasion and were more commonly located in the lower urinary system. These results need to be confirmed with studies based on larger case series. The Korean Society of Pathologists and the Korean Society for Cytopathology 2015-09 2015-09-16 /pmc/articles/PMC4579279/ /pubmed/26395176 http://dx.doi.org/10.4132/jptm.2015.08.10 Text en © 2015 The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Karaarslan, Serap Yaman, Banu Ozturk, Hakan Kumbaraci, Banu Sarsik Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters |
title | Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters |
title_full | Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters |
title_fullStr | Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters |
title_full_unstemmed | Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters |
title_short | Parafibromin Staining Characteristics in Urothelial Carcinomas and Relationship with Prognostic Parameters |
title_sort | parafibromin staining characteristics in urothelial carcinomas and relationship with prognostic parameters |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579279/ https://www.ncbi.nlm.nih.gov/pubmed/26395176 http://dx.doi.org/10.4132/jptm.2015.08.10 |
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