Functional genomics bridges the gap between quantitative genetics and molecular biology

Deep characterization of molecular function of genetic variants in the human genome is becoming increasingly important for understanding genetic associations to disease and for learning to read the regulatory code of the genome. In this paper, I discuss how recent advances in both quantitative genet...

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Detalles Bibliográficos
Autor principal: Lappalainen, Tuuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579327/
https://www.ncbi.nlm.nih.gov/pubmed/26430152
http://dx.doi.org/10.1101/gr.190983.115
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author Lappalainen, Tuuli
author_facet Lappalainen, Tuuli
author_sort Lappalainen, Tuuli
collection PubMed
description Deep characterization of molecular function of genetic variants in the human genome is becoming increasingly important for understanding genetic associations to disease and for learning to read the regulatory code of the genome. In this paper, I discuss how recent advances in both quantitative genetics and molecular biology have contributed to understanding functional effects of genetic variants, lessons learned from eQTL studies, and future challenges in this field.
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spelling pubmed-45793272015-10-01 Functional genomics bridges the gap between quantitative genetics and molecular biology Lappalainen, Tuuli Genome Res Perspective Deep characterization of molecular function of genetic variants in the human genome is becoming increasingly important for understanding genetic associations to disease and for learning to read the regulatory code of the genome. In this paper, I discuss how recent advances in both quantitative genetics and molecular biology have contributed to understanding functional effects of genetic variants, lessons learned from eQTL studies, and future challenges in this field. Cold Spring Harbor Laboratory Press 2015-10 /pmc/articles/PMC4579327/ /pubmed/26430152 http://dx.doi.org/10.1101/gr.190983.115 Text en © 2015 Lappalainen; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Perspective
Lappalainen, Tuuli
Functional genomics bridges the gap between quantitative genetics and molecular biology
title Functional genomics bridges the gap between quantitative genetics and molecular biology
title_full Functional genomics bridges the gap between quantitative genetics and molecular biology
title_fullStr Functional genomics bridges the gap between quantitative genetics and molecular biology
title_full_unstemmed Functional genomics bridges the gap between quantitative genetics and molecular biology
title_short Functional genomics bridges the gap between quantitative genetics and molecular biology
title_sort functional genomics bridges the gap between quantitative genetics and molecular biology
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579327/
https://www.ncbi.nlm.nih.gov/pubmed/26430152
http://dx.doi.org/10.1101/gr.190983.115
work_keys_str_mv AT lappalainentuuli functionalgenomicsbridgesthegapbetweenquantitativegeneticsandmolecularbiology

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