A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy

We show that a common polymorphic variant in the ERCC5 5′ untranslated region (UTR) generates an upstream ORF (uORF) that affects both the background expression of this protein and its ability to be synthesized following exposure to agents that cause bulky adduct DNA damage. Individuals that harbor...

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Detalles Bibliográficos
Autores principales: Somers, Joanna, Wilson, Lindsay A., Kilday, John-Paul, Horvilleur, Emilie, Cannell, Ian G., Pöyry, Tuija A.A., Cobbold, Laura C., Kondrashov, Alexander, Knight, John R.P., Puget, Stéphanie, Grill, Jacques, Grundy, Richard G., Bushell, Martin, Willis, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579346/
https://www.ncbi.nlm.nih.gov/pubmed/26338418
http://dx.doi.org/10.1101/gad.261867.115

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