The effect of genetic bottlenecks and inbreeding on the incidence of two major autoimmune diseases in standard poodles, sebaceous adenitis and Addison’s disease

BACKGROUND: Sebaceous adenitis (SA) and Addison’s disease (AD) increased rapidly in incidence among Standard Poodles after the mid-twentieth century. Previous attempts to identify specific genetic causes using genome wide association studies and interrogation of the dog leukocyte antigen (DLA) regio...

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Detalles Bibliográficos
Autores principales: Pedersen, Niels C., Brucker, Lynn, Tessier, Natalie Green, Liu, Hongwei, Penedo, Maria Cecilia T., Hughes, Shayne, Oberbauer, Anita, Sacks, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579369/
https://www.ncbi.nlm.nih.gov/pubmed/26401342
http://dx.doi.org/10.1186/s40575-015-0026-5

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