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Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

Understanding the extent to which enzyme evolution is reversible can shed light on the fundamental relationship between protein sequence, structure, and function. Here, we perform an experimental test of evolutionary reversibility using directed evolution from a phosphotriesterase to an arylesterase...

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Detalles Bibliográficos
Autores principales: Kaltenbach, Miriam, Jackson, Colin J, Campbell, Eleanor C, Hollfelder, Florian, Tokuriki, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579389/
https://www.ncbi.nlm.nih.gov/pubmed/26274563
http://dx.doi.org/10.7554/eLife.06492

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