High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling

Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C, Tbx5), has recently been demonstrated, suggesting a novel therapeutic strategy for cardiac repair. However, current approaches are inefficien...

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Detalles Bibliográficos
Autores principales: Zhao, Yuanbiao, Londono, Pilar, Cao, Yingqiong, Sharpe, Emily J., Proenza, Catherine, O'Rourke, Rebecca, Jones, Kenneth L., Jeong, Mark Y., Walker, Lori A., Buttrick, Peter M., McKinsey, Timothy A., Song, Kunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579788/
https://www.ncbi.nlm.nih.gov/pubmed/26354680
http://dx.doi.org/10.1038/ncomms9243

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