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Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway

INTRODUCTION: In vitro and animal model of osteoarthritis (OA) studies suggest that TGF-β signalling is involved in OA, but human data is limited. We undertook this study to elucidate the role of TGF-β signalling pathway in OA by comparing the expression levels of TGFB1 and BMP2 as ligands, SMAD3 as...

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Detalles Bibliográficos
Autores principales:	Aref-Eshghi, Erfan, Liu, Ming, Harper, Patricia E., Doré, Jules, Martin, Glynn, Furey, Andrew, Green, Roger, Rahman, Proton, Zhai, Guangju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579831/ https://www.ncbi.nlm.nih.gov/pubmed/26395178 http://dx.doi.org/10.1186/s13075-015-0788-x

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