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Bortezomib attenuates HIF-1- but not HIF-2-mediated transcriptional activation

Bortezomib is the first proteasomal inhibitor (PI) to be used therapeutically for treating relapse cases of multiple myeloma and mantle cell lymphoma. A proposed mechanism for its action is that it prevents the proteasomal degradation of proapoptotic proteins, leading to enhanced apoptosis. Although...

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Detalles Bibliográficos
Autores principales:	ABD-AZIZ, NORAINI, STANBRIDGE, ERIC J., SHAFEE, NORAZIZAH
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579903/ https://www.ncbi.nlm.nih.gov/pubmed/26622817 http://dx.doi.org/10.3892/ol.2015.3545

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