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Exercise Blood Pressure and the Risk for Future Hypertension Among Normotensive Middle‐Aged Adults
BACKGROUND: The aim of the present study was to examine whether exercise blood pressure can be used to predict the development of hypertension in normotensive middle‐aged adults. METHODS AND RESULTS: We investigated 7082 normotensive subjects who were annually screened in a tertiary medical center a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579952/ https://www.ncbi.nlm.nih.gov/pubmed/25904593 http://dx.doi.org/10.1161/JAHA.114.001710 |
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author | Berger, Assaf Grossman, Ehud Katz, Moshe Kivity, Shaye Klempfner, Robert Segev, Shlomo Goldenberg, Ilan Sidi, Yehezkel Maor, Elad |
author_facet | Berger, Assaf Grossman, Ehud Katz, Moshe Kivity, Shaye Klempfner, Robert Segev, Shlomo Goldenberg, Ilan Sidi, Yehezkel Maor, Elad |
author_sort | Berger, Assaf |
collection | PubMed |
description | BACKGROUND: The aim of the present study was to examine whether exercise blood pressure can be used to predict the development of hypertension in normotensive middle‐aged adults. METHODS AND RESULTS: We investigated 7082 normotensive subjects who were annually screened in a tertiary medical center and completed maximal treadmill exercise tests at each visit. After the initial 3 years, subjects were divided into approximate quartiles according to their average exercise systolic and diastolic blood pressure responses (≤158; 158 to 170; 170 to 183; ≥183 mm Hg for systolic blood pressure and ≤73; 73 to 77; 77 to 82; ≥82 mm Hg for diastolic blood pressure). Mean age of the study population was 48±9 years and 73% were men. Average baseline resting blood pressure was 120/77±12/7 mm Hg. During a follow‐up of 5±3 years, 1036 (14.6%) subjects developed hypertension. The cumulative probability of new‐onset hypertension at 5 years was significantly increased with increasing quartiles of exercise systolic blood pressure (5%, 9%, 17%, and 35%, respectively; P<0.001), with a similar association shown for diastolic blood pressure. After adjustment for baseline resting blood pressure and clinical parameters, each 5‐mm Hg increments in exercise either systolic or diastolic blood pressures were independently associated with respective 11% (P<0.001) and 30% (P<0.001) increased risk for the development of hypertension. CONCLUSIONS: In normotensive middle‐aged individuals, blood pressure response to exercise is associated with future development of hypertension. |
format | Online Article Text |
id | pubmed-4579952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45799522015-09-29 Exercise Blood Pressure and the Risk for Future Hypertension Among Normotensive Middle‐Aged Adults Berger, Assaf Grossman, Ehud Katz, Moshe Kivity, Shaye Klempfner, Robert Segev, Shlomo Goldenberg, Ilan Sidi, Yehezkel Maor, Elad J Am Heart Assoc Original Research BACKGROUND: The aim of the present study was to examine whether exercise blood pressure can be used to predict the development of hypertension in normotensive middle‐aged adults. METHODS AND RESULTS: We investigated 7082 normotensive subjects who were annually screened in a tertiary medical center and completed maximal treadmill exercise tests at each visit. After the initial 3 years, subjects were divided into approximate quartiles according to their average exercise systolic and diastolic blood pressure responses (≤158; 158 to 170; 170 to 183; ≥183 mm Hg for systolic blood pressure and ≤73; 73 to 77; 77 to 82; ≥82 mm Hg for diastolic blood pressure). Mean age of the study population was 48±9 years and 73% were men. Average baseline resting blood pressure was 120/77±12/7 mm Hg. During a follow‐up of 5±3 years, 1036 (14.6%) subjects developed hypertension. The cumulative probability of new‐onset hypertension at 5 years was significantly increased with increasing quartiles of exercise systolic blood pressure (5%, 9%, 17%, and 35%, respectively; P<0.001), with a similar association shown for diastolic blood pressure. After adjustment for baseline resting blood pressure and clinical parameters, each 5‐mm Hg increments in exercise either systolic or diastolic blood pressures were independently associated with respective 11% (P<0.001) and 30% (P<0.001) increased risk for the development of hypertension. CONCLUSIONS: In normotensive middle‐aged individuals, blood pressure response to exercise is associated with future development of hypertension. Blackwell Publishing Ltd 2015-04-22 /pmc/articles/PMC4579952/ /pubmed/25904593 http://dx.doi.org/10.1161/JAHA.114.001710 Text en © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Berger, Assaf Grossman, Ehud Katz, Moshe Kivity, Shaye Klempfner, Robert Segev, Shlomo Goldenberg, Ilan Sidi, Yehezkel Maor, Elad Exercise Blood Pressure and the Risk for Future Hypertension Among Normotensive Middle‐Aged Adults |
title | Exercise Blood Pressure and the Risk for Future Hypertension Among Normotensive Middle‐Aged Adults |
title_full | Exercise Blood Pressure and the Risk for Future Hypertension Among Normotensive Middle‐Aged Adults |
title_fullStr | Exercise Blood Pressure and the Risk for Future Hypertension Among Normotensive Middle‐Aged Adults |
title_full_unstemmed | Exercise Blood Pressure and the Risk for Future Hypertension Among Normotensive Middle‐Aged Adults |
title_short | Exercise Blood Pressure and the Risk for Future Hypertension Among Normotensive Middle‐Aged Adults |
title_sort | exercise blood pressure and the risk for future hypertension among normotensive middle‐aged adults |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579952/ https://www.ncbi.nlm.nih.gov/pubmed/25904593 http://dx.doi.org/10.1161/JAHA.114.001710 |
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